Bleeding after antithrombotic therapy in patients with acute ischemic heart disease

被引：6

作者：

Cohen, Marc ^{[1
]}

Alexander, Karen P. ^{[2
]}

Rao, Sunil V. ^{[2
]}

机构：

[1] Newark Beth Israel Med Ctr, Div Cardiol, Newark, NJ 07112 USA

[2] Duke Univ, Med Ctr, Div Cardiol, Durham, NC 27710 USA

来源：

JOURNAL OF THROMBOSIS AND THROMBOLYSIS | 2008年 / 26卷 / 03期

关键词：

Bleeding; Acute coronary syndrome; Hemorrhage; Percutaneous coronary intervention;

D O I：

10.1007/s11239-007-0182-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Definitions of bleeding must be considered when evaluating results of clinical trials. Assessments of bleeding impact based on clinical criteria may be more relevant to patient outcomes than those based on simple laboratory measures like an isolated change in hemoglobin, that do not appear to affect patient care. The risk of excessive bleeding in patients who receive antiplatelet and antithrombotic therapy is related to a combination of patient characteristics (older age, female sex, impaired renal function), and delivery factors (excessive dosing, stacking of anticoagulants). Investigators should justify components of bleeding endpoints as being clinically meaningful, sufficiently frequent in the study population, and affected by the intervention.

引用

页码：175 / 182

页数：8

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