CTL granules: evolution of vesicles essential for combating virus infections

被引：89

作者：

Trapani, JA ^{[1
]}

Sutton, VR ^{[1
]}

Smyth, MJ ^{[1
]}

机构：

[1] Austin Res Inst, Heidelberg, Vic 3084, Australia

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 08期

关键词：

D O I：

10.1016/S0167-5699(99)01488-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viral strategies for escaping apoptosis have co-evolved with the immune system, resulting in a complex balance of pro- and anti-apoptotic forces in virus-infected cells under attack by cytotoxic T lymphocytes (CTLs). Here, Joseph Trapani and colleagues argue that CTL cytolytic granules are the principal apoptotic means of eliminating viruses and possess multiple independent mechanisms to counter the viral anti-apoptotic machinery.

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收藏

页码：351 / 356

页数：6

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