Synthesis and estrogen receptor binding affinity of a porphyrin-estradiol conjugate for targeted photodynamic therapy of cancer

被引：47

作者：

James, DA

Swamy, N

Paz, N

Hanson, RN

Ray, R ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Dept Med, Bioorgan Chem & Struct Biol Grp, Boston, MA 02118 USA

[2] Northeastern Univ, Dept Pharmaceut Sci, Boston, MA 02215 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(99)00390-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A tetraphenylporphyrin-C-11-beta-estradiol conjugate has been synthesized. Competitive binding assay of the conjugate with estrogen receptor (ER)-ligand-binding domain showed that the conjugate binds specifically to the protein with high affinity. Potential use of this conjugate to selectively deliver cytotoxic porphyrins to ER-positive cells in various carcinomas is discussed. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

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页码：2379 / 2384

页数：6

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