Chemotherapy of medulloblastoma

被引:15
作者
Gajjar, A
Kühl, J
Epelman, S
Bailey, C
Allen, J
机构
[1] St Jude Childrens Res Hosp, Memphis, TN 38105 USA
[2] Univ Wurzburg, Kinderklin, D-97080 Wurzburg, Germany
[3] Res Sch Med, Leeds LS2 9LN, W Yorkshire, England
[4] Dept Neurol, New York, NY 10028 USA
关键词
medulloblastoma; risk-adapted therapy; chemotherapy;
D O I
10.1007/s003810050543
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Recent advances in neurosurgical techniques and diagnostic imaging capabilities have facilitated gross total resection and accurate staging of disease extent in a greater proportion of patients. The addition of chemotherapy to surgery and craniospinal radiation has improved the outcome of patients diagnosed with medulloblastoma. Long-term followup studies have documented the neuroendocrine and neuropsychological deficits seen in the survivors. This paper reviews key studies using all three modalities over the past two decades and presents on-going therapeutic strategies using a risk-adapted approach. further areas of basic research and evolving data on studies in relapsed patients are also briefly discussed.
引用
收藏
页码:554 / 562
页数:9
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