The phosphatidylinositol 3-phosphate-binding FYVE finger

被引：163

作者：

Stenmark, H ^{[1
]}

Aasland, R

Driscoll, PC

机构：

[1] Norwegian Radium Hosp, Dept Biochem, N-0310 Oslo, Norway

[2] Univ Bergen, Dept Biol Mol, N-5020 Bergen, Norway

[3] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England

[4] Ludwig Inst Canc Res, London W1W 7BS, England

来源：

FEBS LETTERS | 2002年 / 513卷 / 01期

关键词：

FYVE domain; phosphatidylinositol; 3-kinase; phosphoinositide; membrane traffic; signal transduction;

D O I：

10.1016/S0014-5793(01)03308-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P-containing membranes, and how these proteins serve to regulate multiple cellular functions. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：77 / 84

页数：8

共 55 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, SF
Madden, TL
Schaffer, AA
Zhang, JH
Zhang, Z
Miller, W
Lipman, DJ
[J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (17) : 3389 - 3402
[2] Molecular characterization of an anchor protein (AKAPCE) that binds the RI subunit (RCE) of type I protein kinase A from Caenorhabditis elegans
Angelo, R
Rubin, CS
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (23) : 14633 - 14643
[3] STRUCTURE OF THE C3HC4 DOMAIN BY H-1-NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY - A NEW STRUCTURAL CLASS OF ZINC-FINGER
BARLOW, PN
LUISI, B
MILNER, A
ELLIOTT, M
EVERETT, R
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1994, 237 (02) : 201 - 211
[4] Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins
Bateman, A
Birney, E
Durbin, R
Eddy, SR
Finn, RD
Sonnhammer, ELL
[J]. NUCLEIC ACIDS RESEARCH, 1999, 27 (01) : 260 - 262
[5] PairWise and SearchWise: Finding the optimal alignment in a simultaneous comparison of a protein profile against all DNA translation frames
Birney, E
Thompson, JD
Gibson, TJ
[J]. NUCLEIC ACIDS RESEARCH, 1996, 24 (14) : 2730 - 2739
[6] Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains
Burd, CG
Emr, SD
[J]. MOLECULAR CELL, 1998, 2 (01) : 157 - 162
[7] The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimer
Callaghan, J
Simonsen, A
Gaullier, JM
Toh, BH
Stenmark, H
[J]. BIOCHEMICAL JOURNAL, 1999, 338 : 539 - 543
[8] Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi
Cheung, PCF
Trinkle-Mulcahy, L
Cohen, P
Lucocq, JM
[J]. BIOCHEMICAL JOURNAL, 2001, 355 (01) : 113 - 121
[9] The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S-cerevisiae
Cooke, FT
Dove, SK
McEwen, RK
Painter, G
Holmes, AB
Hall, MN
Michell, RH
Parker, PJ
[J]. CURRENT BIOLOGY, 1998, 8 (22) : 1219 - 1222
[10] A FYVE-finger-containing protein, Rabip4 is a Rab4 effector involved in early endosomal traffic
Cormont, M
Mari, M
Galmiche, A
Hofman, P
Le Marchand-Brustel, Y
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (04) : 1637 - 1642

← 1 2 3 4 5 6 →