Somatostatin receptors and regulation of cell proliferation

被引：41

作者：

Bousquet, C ^{[1
]}

Guillermet, J ^{[1
]}

Vernejoul, F ^{[1
]}

Lahlou, H ^{[1
]}

Buscail, L ^{[1
]}

Susini, C ^{[1
]}

机构：

[1] CHU Rangueil, INSERM, U531, IFR 31, F-31403 Toulouse 4, France

来源：

DIGESTIVE AND LIVER DISEASE | 2004年 / 36卷

关键词：

antioncogene; apoptosis; inhibition; proliferation; receptors; somatostatin; sst2;

D O I：

10.1016/j.dld.2003.11.007

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Somatostatin is an inhibitory neuropeptide, which acts on various targets throughout the body to regulate a variety of physiological functions including inhibition of endocrine and exocrine secretions, modulation of neurotransmission, motor and cognitive functions, inhibition of intestinal motility, absorption of nutrients and ions, vascular contractility and inhibition of normal and tumour cell proliferation. It exerts its effects through interaction with five somatostatin receptors (sstl-sst5), which belong to the family of G-protein-coupled receptors with seven transmembrane spanning domains and are variably expressed in a variety of tumours such as gastroenteropancreatic tumours, pituitary tumours, and carcinoid tumours. This review covers the present knowledge regarding the molecular mechanisms involved in somatostatin antineoplastic activity. Evidence that sst2 receptor acts as a tumour suppressor is also discussed. (C) 2003 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：S2 / S7

页数：6

共 63 条

[1] Somatostatin controls Kaposi's sarcoma tumor growth through inhibition of angiogenesis [J].

Albini, A ;

Florio, T ;

Giunciuglio, D ;

Masiello, L ;

Carlone, S ;

Corsaro, A ;

Thellung, S ;

Cai, T ;

Noonan, DM ;

Schettini, G .

FASEB JOURNAL, 1999, 13 (06) :647-655

[2] Rat somatostatin sst2(a) and sst2(b) receptor isoforms mediate opposite effects on cell proliferation [J].

Alderton, F ;

Fan, TPD ;

Schindler, M ;

Humphrey, PPA .

BRITISH JOURNAL OF PHARMACOLOGY, 1998, 125 (08) :1630-1633

[3] High-intensity p38 kinase activity is critical for p21cip1 induction and the antiproliferative function of Gi protein-coupled receptors [J].

Alderton, F ;

Humphrey, PPA ;

Sellers, LA .

MOLECULAR PHARMACOLOGY, 2001, 59 (05) :1119-1128

[4] Somatostatin analogue octreotide and inhibition of tumour growth in metastatic endocrine gastroenteropancreatic tumours [J].

Arnold, R ;

Trautmann, ME ;

Creutzfeldt, W ;

Benning, R ;

Benning, M ;

Neuhaus, C ;

Jurgensen, R ;

Stein, K ;

Schafer, H ;

Bruns, C ;

Dennler, HJ .

GUT, 1996, 38 (03) :430-438

[5] Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238 [J].

Benali, N ;

Cordelier, P ;

Calise, D ;

Pagès, P ;

Rochaix, P ;

Nagy, A ;

Estève, JP ;

Pour, PM ;

Schally, AV ;

Vaysse, N ;

Susini, C ;

Buscail, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (16) :9180-9185

[6]

BITO H, 1994, J BIOL CHEM, V269, P12722

[7] sst2 somatostatin receptor mediates negative regulation of insulin receptor signaling through the tyrosine phosphatase SHP-1 [J].

Bousquet, C ;

Delesque, N ;

Lopez, F ;

Saint-Laurent, N ;

Estève, JP ;

Bedecs, K ;

Buscail, L ;

Vaysse, N ;

Susini, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (12) :7099-7106

[8] Somatostatin, acting at receptor subtype 1, inhibits Rho activity, the assembly of actin stress fibers, and cell migration [J].

Buchan, AMJ ;

Lin, CY ;

Choi, J ;

Barber, DL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (32) :28431-28438

[9] INHIBITION OF CELL-PROLIFERATION BY THE SOMATOSTATIN ANALOG RC-160 IS MEDIATED BY SOMATOSTATIN RECEPTOR SUBTYPES SSTR2 AND SSTR5 THROUGH DIFFERENT MECHANISMS [J].

BUSCAIL, L ;

ESTEVE, JP ;

SAINTLAURENT, N ;

BERTRAND, V ;

REISINE, T ;

OCARROLL, AM ;

BELL, GI ;

SCHALLY, AV ;

VAYSSE, N ;

SUSINI, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) :1580-1584

[10]

Buscail L, 1996, CANCER RES, V56, P1823

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