学术探索
学术期刊
学术作者
新闻热点
数据分析
智能评审

Oxidized LDL induces procoagulant profiles by increasing lysophosphatidylcholine levels, lysophosphatidylethanolamine levels, and Lp-PLA2 activity in borderline hypercholesterolemia

被引：35
作者：
Kim, Minjoo [1 ]
Yoo, Hye Jin [2 ,3 ]
Lee, Dahyoung [3 ,4 ]
Lee, Jong Ho [2 ,3 ,4 ]
机构：
[1] Hannam Univ, Dept Food & Nutr, Coll Life Sci & Nano Technol, Daejeon, South Korea
[2] Yonsei Univ, Inst Symbiot Life TECH, Res Ctr Silver Sci, Seoul, South Korea
[3] Yonsei Univ, Dept Food & Nutr, Coll Human Ecol, Natl Leading Res Lab Clin Nutrigenet Nutrigen, Seoul, South Korea
[4] Yonsei Univ, Coll Human Ecol, Brain Korea 21 PLUS Project, Dept Food & Nutr, Seoul, South Korea
来源：
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2020年 / 30卷 / 07期
基金：
新加坡国家研究基金会;
关键词：
Oxidized LDL; Prothrombin time; Activated partial thromboplastin time; Lp-PLA(2) activity; Lysophosphatidylcholines; Lysophosphatidylethanolamines; PARTIAL THROMBOPLASTIN TIME; LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE-CELLS; PHOSPHOLIPASE A(2); OXIDATIVE STRESS; PROTHROMBIN TIME; CD40; LIGAND; RISK; DISEASE; INHIBITION;
D O I：
10.1016/j.numecd.2020.03.015
中图分类号：
R5 [内科学];
学科分类号：
100201 [内科学];
摘要：
Background and aims: The increased risk of cardiovascular disease under hypercholesterolemia is due to associations between oxidized low-density lipoprotein (ox-LDL) and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and between ox-LDL and coagulant profiles. We investigated the impact of different ox-LDL levels on coagulation time and plasma metabolomes in subjects with borderline hypercholesterolemia. Methods and results: One hundred thirty-one subjects with borderline hypercholesterolemia (serum cholesterol >= 200 mg/dL) were divided into low ox-LDL (n = 66) and high ox-LDL (n = 65) groups. After adjusting for confounding factors, the high ox-LDL group exhibited a significantly decreased activated partial thromboplastin time (aPTT) and prothrombin time (PT) and increased Lp-PLA(2) activity. Compared to the low ox-LDL group, the high ox-LDL group exhibited significantly increased intensities of 17 lysophosphatidylcholines (lysoPCs) and 7 lysophosphatidylethanolamines (lysoPEs). Ox-LDL was inversely correlated with aPTT and PT and positively correlated with Lp-PLA(2) activity. Positive correlations were also found among oxLDL, Lp-PLA(2) activity, lysoPCs, and lysoPEs. LysoPCs and lysoPEs were inversely correlated with PT and aPTT. The identified plasma metabolites, including amino acids, fatty acid amides, acylcarnitines, and lysophospholipids, were significantly upregulated in the high ox-LDL group. Conclusion: High ox-LDL levels may be involved in the development of a procoagulant state in subjects with borderline hypercholesterolemia by increasing Lp-PLA(2) activity and lysoPC and lysoPE levels. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1137 / 1146
页数：10
相关论文
共 50 条
[1]
Fatty acyl composition of lysophosphatidylcholine is important in atherosclerosis [J].
Akerele, O. A. ;
Cheema, S. K. .
MEDICAL HYPOTHESES, 2015, 85 (06) :754-760
[2]
Intrinsic pathway of blood coagulation contributes to thrombogenicity of atherosclerotic plaque [J].
Ananyeva, NM ;
Kouiavskaia, DV ;
Shima, M ;
Saenko, EL .
BLOOD, 2002, 99 (12) :4475-4485
[3]
[Anonymous], SOONCHUNHYANG MED SC
[4]
Local inhibition of tissue factor reduces the thrombogenicity of disrupted human atherosclerotic plaques - Effects of tissue factor pathway inhibitor on plaque thrombogenicity under flow conditions [J].
Badimon, JJ ;
Lettino, M ;
Toschi, V ;
Fuster, V ;
Berrozpe, M ;
Chesebro, JH ;
Badimon, L .
CIRCULATION, 1999, 99 (14) :1780-1787
[5]
Plasma very-low-density lipoprotein, low-density lipoprotein, and high-density lipoprotein oxidative modification induces procoagulant profiles in endogenous hypertriglyceridemia [J].
Bai, Huai ;
Liu, Bing-Wen ;
Deng, Zu-Yue ;
Shen, Tao ;
Fang, Ding-Zhi ;
Zhao, Yu-Hua ;
Liu, Yu .
FREE RADICAL BIOLOGY AND MEDICINE, 2006, 40 (10) :1796-1803
[6]
Lipidomic approaches to the study of phospholipase A2-regulated phospholipid fatty acid incorporation and remodeling [J].
Balgoma, David ;
Montero, Olimpio ;
Balboa, Maria A. ;
Balsinde, Jesus .
BIOCHIMIE, 2010, 92 (06) :645-650
[7]
Bhalodia YS, 2010, INT J PHARMACOL, V6, P25
[8]
Lipoprotein-associated phospholipase A2:: a new biomarker for cardiovascular risk assessment and potential therapeutic target [J].
Carlquist, John F. ;
Muhlestein, Joseph B. ;
Anderson, Jeffrey L. .
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2007, 7 (05) :511-517
[9]
Association of Lp-PLA2 activity and LDL size with interleukin-6, an inflammatory cytokine and oxidized LDL, a marker of oxidative stress, in women with metabolic syndrome [J].
Chae, Jey Sook ;
Kim, Oh Yoen ;
Paik, Jean Kyung ;
Kang, Ryungwoo ;
Seo, Woo Ju ;
Jeong, Tae-Sook ;
Sweeney, Gary ;
Lee, Sang-Hyun ;
Lee, Jong Ho .
ATHEROSCLEROSIS, 2011, 218 (02) :499-506
[10]
Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].
Cleeman, JI ;
Grundy, SM ;
Becker, D ;
Clark, LT ;
Cooper, RS ;
Denke, MA ;
Howard, WJ ;
Hunninghake, DB ;
Illingworth, DR ;
Luepker, RV ;
McBride, P ;
McKenney, JM ;
Pasternak, RC ;
Stone, NJ ;
Van Horn, L ;
Brewer, HB ;
Ernst, ND ;
Gordon, D ;
Levy, D ;
Rifkind, B ;
Rossouw, JE ;
Savage, P ;
Haffner, SM ;
Orloff, DG ;
Proschan, MA ;
Schwartz, JS ;
Sempos, CT ;
Shero, ST ;
Murray, EZ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497
12345