Mouse ooplasm confers context-specific reprogramming capacity

被引：55

作者：

Chan, Michelle M. ^{[1
,2
]}

Smith, Zachary D. ^{[1
,3
,4
]}

Egli, Dieter ^{[5
]}

Regev, Aviv ^{[1
,6
,7
]}

Meissner, Alexander ^{[1
,3
,4
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[2] MIT, Computat & Syst Biol Program, Cambridge, MA 02139 USA

[3] Harvard Stem Cell Inst, Cambridge, MA USA

[4] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

[5] New York Stem Cell Fdn Lab, New York, NY USA

[6] MIT, Dept Biol, Cambridge, MA USA

[7] MIT, Howard Hughes Med Inst, Cambridge, MA USA

来源：

NATURE GENETICS | 2012年 / 44卷 / 09期

基金：

美国国家卫生研究院;

关键词：

MAMMALIAN DEVELOPMENT; DNA METHYLATION; 5-HYDROXYMETHYLCYTOSINE; OOCYTES; ZYGOTES; GENOME;

D O I：

10.1038/ng.2382

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes.

引用

页码：978 / 980

页数：3

共 15 条

[1] Quantitative Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution [J].

Booth, Michael J. ;

Branco, Miguel R. ;

Ficz, Gabriella ;

Oxley, David ;

Krueger, Felix ;

Reik, Wolf ;

Balasubramanian, Shankar .

SCIENCE, 2012, 336 (6083) :934-937

[2] Uncovering the role of 5-hydroxymethylcytosine in the epigenome [J].

Branco, Miguel R. ;

Ficz, Gabriella ;

Reik, Wolf .

NATURE REVIEWS GENETICS, 2012, 13 (01) :7-13

[3] Conservation of methylation reprogramming in mammalian development: Aberrant reprogramming in cloned embryos [J].

Dean, W ;

Santos, F ;

Stojkovic, M ;

Zakhartchenko, V ;

Walter, J ;

Wolf, E ;

Reik, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (24) :13734-13738

[4] Reprogramming within hours following nuclear transfer into mouse but not human zygotes [J].

Egli, Dieter ;

Chen, Alice E. ;

Saphier, Genevieve ;

Ichida, Justin ;

Fitzgerald, Claire ;

Go, Kathryn J. ;

Acevedo, Nicole ;

Patel, Jay ;

Baetscher, Manfred ;

Kearns, William G. ;

Goland, Robin ;

Leibel, Rudolph L. ;

Melton, Douglas A. ;

Eggan, Kevin .

NATURE COMMUNICATIONS, 2011, 2

[5] A novel active L1 retrotransposon subfamily in the mouse [J].

Goodier, JL ;

Ostertag, EM ;

Du, K ;

Kazazian, HH .

GENOME RESEARCH, 2001, 11 (10) :1677-1685

[6] The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes [J].

Gu, Tian-Peng ;

Guo, Fan ;

Yang, Hui ;

Wu, Hai-Ping ;

Xu, Gui-Fang ;

Liu, Wei ;

Xie, Zhi-Guo ;

Shi, Linyu ;

He, Xinyi ;

Jin, Seung-gi ;

Iqbal, Khursheed ;

Shi, Yujiang Geno ;

Deng, Zixin ;

Szabo, Piroska E. ;

Pfeifer, Gerd P. ;

Li, Jinsong ;

Xu, Guo-Liang .

NATURE, 2011, 477 (7366) :606-U136

[7] Genome-scale DNA methylation maps of pluripotent and differentiated cells [J].

Meissner, Alexander ;

Mikkelsen, Tarjei S. ;

Gu, Hongcang ;

Wernig, Marius ;

Hanna, Jacob ;

Sivachenko, Andrey ;

Zhang, Xiaolan ;

Bernstein, Bradley E. ;

Nusbaum, Chad ;

Jaffe, David B. ;

Gnirke, Andreas ;

Jaenisch, Rudolf ;

Lander, Eric S. .

NATURE, 2008, 454 (7205) :766-U91

[8] Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription [J].

Ng, Ray Kit ;

Gurdon, J. B. .

NATURE CELL BIOLOGY, 2008, 10 (01) :102-U83

[9] Hypomethylation of paternal DNA in the late mouse zygote is not essential for development [J].

Polanski, Zbigniew ;

Motosugi, Nami ;

Tsurumi, Chizuko ;

Hiiragi, Takashi ;

Hoffmann, Steffen .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2008, 52 (2-3) :295-298

[10] Epigenetic reprogramming in mammalian development [J].

Reik, W ;

Dean, W ;

Walter, J .

SCIENCE, 2001, 293 (5532) :1089-1093

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