Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease

被引：1000

作者：

Auluck, PK

Chan, HYE

Trojanowski, JQ

Lee, VMY

Bonini, NM ^{[1
]}

机构：

[1] Univ Penn, Dept Neurosci, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

[3] Univ Penn, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA

[4] Univ Penn, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

[5] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[6] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

来源：

SCIENCE | 2002年 / 295卷 / 5556期

关键词：

D O I：

10.1126/science.1067389

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Parkinson's disease is a movement disorder characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta. Dopaminergic neuronal loss also occurs in Drosophila melanogaster upon directed expression of alpha-synuclein, a protein implicated in the pathogenesis of Parkinson's disease and a major component of proteinaceous Lewy bodies. We report that directed expression of the molecular chaperone, Hsp70 prevented dopaminergic neuronal loss associated with alpha-synuclein in Drosophila and that interference with endogenous chaperone activity accelerated alpha-synuclein toxicity. Furthermore, Lewy bodies in human postmortem tissue immunostained for molecular chaperones, also suggesting that chaperones may play a role in Parkinson's disease progression.

引用

页码：865 / 868

页数：4

共 22 条

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