C1qB and clusterin mRNA increase in association with neurodegeneration in sporadic amyotrophic lateral sclerosis

被引：52

作者：

Grewal, RP

Morgan, TE

Finch, CE

机构：

[1] Univ So Calif, Sch Med, Dept Neurol, Los Angeles, CA 90089 USA

[2] Univ So Calif, Andrus Gerontol Ctr, Los Angeles, CA 90089 USA

[3] Univ So Calif, Dept Sci Biol, Los Angeles, CA 90089 USA

来源：

NEUROSCIENCE LETTERS | 1999年 / 271卷 / 01期

关键词：

amyotrophic lateral sclerosis; mRNA; clusterin; complement; inflammation; neurodegeneration;

D O I：

10.1016/S0304-3940(99)00496-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We analyzed postmortem tissues of sporadic amyotrophic lateral sclerosis (SALS) for mRNA levels of two inflammatory proteins, complement C1qB and clusterin (apoJ). By Northern blot hybridization, SALS was associated with increased mRNA for C1qB and clusterin in the motor cortex (Brodmann area A4), but not in superior temporal cortex (A17), relative to neurologically normal controls. By in situ hybridization, SALS spinal cords showed increased C1qB and clusterin mRNA in areas undergoing neurodegeneration. This evidence implicates inflammatory mechanisms during neurodegenerative processes in SALS. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：65 / 67

页数：3

共 18 条

[1] HUMAN GLIOMAS AND EPILEPTIC FOCI EXPRESS HIGH-LEVELS OF A MESSENGER-RNA RELATED TO RAT TESTICULAR SULFATED GLYCOPROTEIN-2, A PURPORTED MARKER OF CELL-DEATH [J].