Synthesis of 8-oxo-7,8-dihydro-6-O-methyl-2'-deoxyguanosine and its use as a probe to study DNA-base excision by MutY enzyme

被引:8
作者
Varaprasad, CV [1 ]
Bulychev, N [1 ]
Grollman, AP [1 ]
Johnson, F [1 ]
机构
[1] SUNY STONY BROOK,HLTH SCI CTR,SCH MED,DEPT PHARMACOL SCI,STONY BROOK,NY 11794
关键词
D O I
10.1016/0040-4039(95)02069-1
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A 23mer oligomer containing 8-oxo-7,8-dihydro-6-O-methyl-2'-deoxyguanosine (1) has been synthesized from 2'-deoxyguanosine. The activity of MutY protein coward this and a related oligomer containing 8-methoxy-dG has been studied.
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页码:9 / 12
页数:4
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