Synthesis of 8-oxo-7,8-dihydro-6-O-methyl-2'-deoxyguanosine and its use as a probe to study DNA-base excision by MutY enzyme

被引：8

作者：

Varaprasad, CV ^{[1
]}

Bulychev, N ^{[1
]}

Grollman, AP ^{[1
]}

Johnson, F ^{[1
]}

机构：

[1] SUNY STONY BROOK,HLTH SCI CTR,SCH MED,DEPT PHARMACOL SCI,STONY BROOK,NY 11794

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 01期

关键词：

D O I：

10.1016/0040-4039(95)02069-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A 23mer oligomer containing 8-oxo-7,8-dihydro-6-O-methyl-2'-deoxyguanosine (1) has been synthesized from 2'-deoxyguanosine. The activity of MutY protein coward this and a related oligomer containing 8-methoxy-dG has been studied.

引用

页码：9 / 12

页数：4

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