Pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces delayed neuronal death following transient forebrain ischemia in the adult rat hippocampus

被引：26

作者：

Daimon, M

Aomi, S

Kawamata, T

Kurosawa, H

机构：

[1] Tokyo Womens Med Univ, Heart Inst Japan, Dept Cardiovasc Surg, Shinjuku Ku, Tokyo 1628666, Japan

[2] Tokyo Womens Med Univ, Neurol Inst, Dept Neurosurg, Tokyo, Japan

来源：

NEUROSCIENCE LETTERS | 2004年 / 362卷 / 02期

关键词：

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor; delayed neuronal death; transient forebrain ischemia; prophylactic statin treatment;

D O I：

10.1016/j.neulet.2004.03.012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent evidence indicates that statins have beneficial effects on the brain in the ischemic condition. However, there is a lack of studies related to the effect of statins on delayed neuronal death. We investigated the effect of prophylactic therapy with pravastatin on delayed neuronal death in the rat hippocampus. The rats were given a daily dose of 20 mg/kg of pravastatin orally for 14 days. Transient forebrain ischemia was induced by the four-vessel occlusion method. Three days after ischemia, surviving neurons of the hippocampal CA1 subfield were counted. Our results demonstrated that prophylactic statin treatment significantly reduced delayed neuronal death after transient forebrain ischemia. Our findings suggest that prophylactic statin treatment may be useful in preventing functional neurological disorders after transient cerebral ischemic insult. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

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页码：122 / 126

页数：5

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