Genetic analysis of axon guidance and mapping in the zebrafish

被引：28

作者：

Karlstrom, RO ^{[1
]}

Trowe, T ^{[1
]}

Bonhoeffer, F ^{[1
]}

机构：

[1] MAX PLANCK INST ENTWICKLUNGSBIOL,D-72076 TUBINGEN,GERMANY

来源：

TRENDS IN NEUROSCIENCES | 1997年 / 20卷 / 01期

关键词：

D O I：

10.1016/S0166-2236(96)40005-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Systematic genetic screens have been powerful tools in identifying genes responsible for axon guidance in fruitflies and nematodes. This approach has now been extended to the study of axon guidance and the formation of topographic neuronal connections in the vertebrate brain. A systematic genetic screen was used to identify genes responsible for precise axon pathfinding and targeting in the retinotectal system of the zebrafish (Danio rerio). Over 30 genes were found that affect either: (1) retinal axon pathfinding to the contralateral tectal lobe; or (2) the topographic connection between the eye and the tectum. The zebrafish retinotectal mutants represent a new resource for the study of axon guidance in the vertebrate brain.

引用

页码：3 / 8

页数：6

共 48 条

[1]

Baier H, 1996, DEVELOPMENT, V123, P415

[2] GROWTH CONE GUIDANCE BY FLOOR PLATE CELLS IN THE SPINAL-CORD OF ZEBRAFISH EMBRYOS [J].

BERNHARDT, RR ;

NGUYEN, N ;

KUWADA, JY .

NEURON, 1992, 8 (05) :869-882

[3] Telling axons where to grow: A role for Eph receptor tyrosine kinases in guidance [J].

Brambilla, R ;

Klein, R .

MOLECULAR AND CELLULAR NEUROSCIENCE, 1995, 6 (06) :487-495

[4] A BEHAVIORAL SCREEN FOR ISOLATING ZEBRAFISH MUTANTS WITH VISUAL-SYSTEM DEFECTS [J].

BROCKERHOFF, SE ;

HURLEY, JB ;

JANSSENBIENHOLD, U ;

NEUHAUSS, SCF ;

DRIEVER, W ;

DOWLING, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (23) :10545-10549

[5]

BURRILL JD, 1995, J NEUROSCI, V15, P2935

[6] AXONAL GUIDANCE FROM RETINA TO TECTUM IN EMBRYONIC XENOPUS [J].

CHIEN, CB ;

HARRIS, WA .

CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 29, 1994, 29 :135-169

[7] THE AXONAL CHEMOATTRACTANT NETRIN-1 IS ALSO A CHEMOREPELLENT FOR TROCHLEAR MOTOR AXONS [J].

COLAMARINO, SA ;

TESSIERLAVIGNE, M .

CELL, 1995, 81 (04) :621-629

[8] IN-VITRO GUIDANCE OF RETINAL GANGLION-CELL AXONS BY RAGS, A 25 KDA TECTAL PROTEIN RELATED TO LIGANDS FOR EPH RECEPTOR TYROSINE KINASES [J].

DRESCHER, U ;

KREMOSER, C ;

HANDWERKER, C ;

LOSCHINGER, J ;

NODA, M ;

BONHOEFFER, F .

CELL, 1995, 82 (03) :359-370

[9] REVERSED VISUOMOTOR BEHAVIOR MEDIATED BY INDUCED IPSILATERAL RETINAL PROJECTIONS IN GOLDFISH [J].

EASTER, SS ;

SCHMIDT, JT .

JOURNAL OF NEUROPHYSIOLOGY, 1977, 40 (06) :1245-1254

[10] Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein [J].

Garrity, PA ;

Rao, Y ;

Salecker, I ;

McGlade, J ;

Pawson, T ;

Zipursky, SL .

CELL, 1996, 85 (05) :639-650

← 1 2 3 4 5 →