A new tyrosine kinase inhibitor from the marine brown alga Stypopodium zonale

被引：58

作者：

Wessels, M ^{[1
]}

König, GM ^{[1
]}

Wright, AD ^{[1
]}

机构：

[1] Tech Univ Braunschweig, Inst Pharmaceut Biol, D-38106 Braunschweig, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 06期

关键词：

D O I：

10.1021/np990010h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From the lipophilic extract of the marine brown alga Stypopodium zonale (Dictyotaceae) the new terpenoid compound stypoquinonic acid (1) together with the known compounds taondiol (2) and atomaric acid (3) were isolated. The structures of all isolates were determined from their spectroscopic data, including 1- and a-dimensional NMR methods. The new compound, 1, and atomaric acid (3), showed inhibition of tyrosine kinase (p56(lck)).

引用

页码：927 / 930

页数：4

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