Nanocrystal Core High-Density Lipoproteins: A Multimodality Contrast Agent Platform

被引：261

作者：

Cormode, David P. ^{[1
]}

Skajaa, Torjus ^{[1
,2
]}

van Schooneveld, Matti M. ^{[3
]}

Koole, Rolf ^{[3
]}

Jarzyna, Peter ^{[1
]}

Lobatto, Mark E. ^{[1
]}

Calcagno, Claudia ^{[1
]}

Barazza, Alessandra ^{[1
,3
]}

Gordon, Ronald E. ^{[1
,6
]}

Zanzonico, Pat ^{[7
,8
]}

Fisher, Edward A. ^{[4
,5
]}

Fayad, Zahi A. ^{[1
]}

Mulder, Willem J. M. ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Translat & Mol Imaging Inst, New York, NY 10029 USA

[2] Aarhus Univ, Fac Hlth Sci, DK-8000 Aarhus C, Denmark

[3] Univ Utrecht, Debye Inst, NL-3584 CC Utrecht, Netherlands

[4] NYU, Dept Med Cardiol, Marc & Ruti Bell Vasc Biol & Dis Program, Sch Med, New York, NY 10016 USA

[5] NYU, NYU Ctr Prevent Cardiovasc Dis, Sch Med, New York, NY 10016 USA

[6] Mt Sinai Hosp, Dept Pathol, New York, NY 10029 USA

[7] Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY 10021 USA

[8] Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10021 USA

来源：

NANO LETTERS | 2008年 / 8卷 / 11期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1021/nl801958b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

High density lipoprotein (HDL) is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique to create unique multimodality HDL mimicking nanoparticles by incorporation of gold, iron oxide, or quantum dot nanocrystals for computed tomography, magnetic resonance, and fluorescence imaging, respectively. By including additional labels in the corona of the particles, they were made multifunctional. The characteristics of these nanoparticles, as well as their in vitro and in vivo behavior, revealed that they closely mimic native HDL.

引用

页码：3715 / 3723

页数：9

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