Journey through the thymus: stromal guides for T-cell development and selection

被引：493

作者：

Takahama, Y ^{[1
]}

机构：

[1] Univ Tokushima, Inst Genome Res, Div Expt Immunol, Tokushima 7708503, Japan

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 02期

基金：

日本学术振兴会;

关键词：

D O I：

10.1038/nri1781

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lympho-stromal interactions in multiple microenvironments within the thymus have a crucial role in the regulation of T-cell development and selection. Recent studies have implicated that chemokines that are produced by thymic stromal cells have a pivotal role in positioning developing T cells within the thymus. In this Review, I discuss the importance of stroma-derived chemokines in guiding the traffic of developing thymocytes, with an emphasis on the processes of cortex-to-medulla migration and T-cell-repertoire selection, including central tolerance.

引用

页码：127 / 135

页数：9

共 118 条

[1] An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains [J].

Aaltonen, J ;

Bjorses, P ;

Perheentupa, J ;

HorelliKuitunen, N ;

Palotie, A ;

Peltonen, L ;

Lee, YS ;

Francis, F ;

Hennig, S ;

Thiel, C ;

Lehrach, H ;

Yaspo, ML .

NATURE GENETICS, 1997, 17 (04) :399-403

[2] Dependence of self-tolerance on TRAF6-directed development of thymic stroma [J].

Akiyama, T ;

Maeda, S ;

Yamane, S ;

Ogino, K ;

Kasai, M ;

Kajiura, F ;

Matsumoto, M ;

Inoue, J .

SCIENCE, 2005, 308 (5719) :248-251

[3] Compartmentalized production of CCL17 in vivo:: Strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen [J].

Alferink, J ;

Lieberam, I ;

Reindl, W ;

Behrens, A ;

Weiss, S ;

Hüser, N ;

Gerauer, K ;

Ross, R ;

Reske-Kunz, AB ;

Ahmad-Nejad, P ;

Wagner, H ;

Förster, I .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (05) :585-599

[4] Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration [J].

Allende, ML ;

Dreier, JL ;

Mandala, S ;

Proia, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (15) :15396-15401

[5] The cellular mechanism of Aire control of T cell tolerance [J].

Anderson, MS ;

Venanzi, ES ;

Chen, ZB ;

Berzins, SP ;

Benoist, C ;

Mathis, D .

IMMUNITY, 2005, 23 (02) :227-239

[6] Projection of an immunological self shadow within the thymus by the aire protein [J].

Anderson, MS ;

Venanzi, ES ;

Klein, L ;

Chen, ZB ;

Berzins, SP ;

Turley, SJ ;

von Boehmer, H ;

Bronson, R ;

Dierich, A ;

Benoist, C ;

Mathis, D .

SCIENCE, 2002, 298 (5597) :1395-1401

[7] Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: Possible implications for negative selection [J].

Annunziato, F ;

Romagnani, P ;

Cosmi, L ;

Beltrame, C ;

Steiner, BH ;

Lazzeri, E ;

Raport, CJ ;

Galli, G ;

Manetti, R ;

Mavilia, C ;

Vanini, V ;

Chantry, D ;

Maggi, E ;

Romagnani, S .

JOURNAL OF IMMUNOLOGY, 2000, 165 (01) :238-246

[8] A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo [J].

Ara, T ;

Itoi, M ;

Kawabata, K ;

Egawa, T ;

Tokoyoda, K ;

Sugiyama, T ;

Fujii, N ;

Amagai, T ;

Nagasawa, T .

JOURNAL OF IMMUNOLOGY, 2003, 170 (09) :4649-4655

[9] SUCCESSFUL ENGRAFTMENT OF HUMAN POSTNATAL THYMUS IN SEVERE COMBINED IMMUNE DEFICIENT (SCID) MICE - DIFFERENTIAL ENGRAFTMENT OF THYMIC COMPONENTS WITH IRRADIATION VERSUS ANTI-ASIALO GM-1 IMMUNOSUPPRESSIVE REGIMENS [J].

BARRY, TS ;

JONES, DM ;

RICHTER, CB ;

HAYNES, BF .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (01) :167-180

[10] ACTIVATION EVENTS DURING THYMIC SELECTION [J].

BENDELAC, A ;

MATZINGER, P ;

SEDER, RA ;

PAUL, WE ;

SCHWARTZ, RH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (03) :731-742

← 1 2 3 4 5 6 7 8 9 10 →