Inheritance of polymorphic metabolizing genes on environmental disease and quality of life

被引：13

作者：

Au, WW ^{[1
]}

Sierra-Torres, CH ^{[1
]}

Cajas-Salazar, N ^{[1
]}

Salama, SA ^{[1
]}

机构：

[1] Univ Texas, Med Branch, Dept Prevent Med & Community Hlth, Galveston, TX 77555 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1999年 / 428卷 / 1-2期

关键词：

genetic susceptibility; chromosome aberration; cigarette smoking; occupational exposure; environmental disease; quality of life;

D O I：

10.1016/S1383-5742(99)00041-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

From investigations based on the human genome and the environmental genome programs, genetic basis for individual differences in response to environmental mutagens is being characterized. Inheritance of variant versions of certain polymorphic genes is frequently associated with the development of environmental disease, such as lung cancer from cigarette smoking. Inheritance of these alleles may also affect the quality of life such as longevity. Evidence in support of these possibilities is presented. It is obvious that through the understanding of susceptibility, more precise disease prevention strategies can be implemented which will not only reduce the disease burden but also improve the quality of life. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：131 / 140

页数：10

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