The role of human T-lymphocyte-monocyte contact in inflammation and tissue destruction

被引：100

作者：

Burger, Danielle ^{[1
]}

Dayer, Jean-Michel ^{[1
]}

机构：

[1] Univ Hosp, Div Immunol & Allergy, Clin Immunol Unit, Geneva, Switzerland

来源：

ARTHRITIS RESEARCH & THERAPY | 2002年 / 4卷 / Suppl 3期

基金：

瑞士国家科学基金会;

关键词：

cytokines; inflammation; monocytes; rheumatoid arthritis; T lymphocytes;

D O I：

10.1186/ar558

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Contact-mediated signaling of monocytes by human stimulated T lymphocytes (T-L) is a potent proinflammatory mechanism that triggers massive upregulation of the proinflammatory cytokines IL-1 and tumor necrosis factor-alpha. These two cytokines play an important part in chronic destructive diseases, including rheumatoid arthritis. To date this cell-cell contact appears to be a major endogenous mechanism to display such an activity in monocyte-macrophages. Since T-L and monocyte-macrophages play a pivotal part in the pathogenesis of chronic inflammatory diseases, we investigated the possible ligands and counter-ligands involved in this cell-cell interaction. We also characterized an inhibitory molecule interfering in this process, apolipoprotein A-I. This review aims to summarize the state of the art and importance of contact-mediated monocyte activation by stimulated T-L in cytokine production in rheumatoid arthritis and mechanisms that might control it.

引用

页码：S169 / S176

页数：8

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