Rapid Screening of Cognitive Change in Patients with Questionable Dementia Using the Memory Impairment Screen and the Isaacs Set Test

To assess the efficacy of combining the Memory Impairment Screen (MIS) and the Isaacs Set Test (IST) in predicting short-term development of dementia in a group of people with questionable dementia (QD) at baseline. Performances of the weighted sum of MIS and IST and the < or > rule were compared with each other and with the Mini-Mental State Examination. Database of the Regional Network for Diagnostic Aid and Management of Patients with Cognitive Impairment in the Franche-ComtE geographical area in France. A cohort of 106 patients aged 65 and older with QD were followed up for a mean of 14.9 months (range 6-24 months). Sensitivity, specificity, positive predictive value, and negative predictive value were calculated for the combination of these two tests. The weighted sum had a sensitivity of 0.74 and a specificity of 0.84. The < or > rule (MIS < 6 or IST < 25) had a sensitivity of 0.74 and a specificity of 0.81. When range values were applied, low scores on the MIS and the IST (MIS < 6 and IST < 25) led to a high probability of dementia, whereas high scores (MIS > 7 and IST > 29) suggested a high probability of remaining dementia-free in the study follow-up. This quickly performed tool (5 minutes) is simple to use and score. When including cutscores (MIS < 6 or IST < 25) or range values, this test could be considered a useful screening procedure for all types of dementias.