A halotype-based study of lithium responding patients with bipolar affective disorder on the Faroe Islands

被引:34
作者
Ewald, H
Wang, AG
Vang, M
Mors, O
Nyegaard, M
Kruse, TA
机构
[1] Hosp Psychiat, Inst Basic Psychiat Res, Dept Psychiat Demog, DK-8240 Risskov, Denmark
[2] Hosp Psychiat, Dept Biol Psychiat, DK-8240 Risskov, Denmark
[3] Natl Hosp, Dept Psychiat, Torshavn, Faroe Islands, Denmark
[4] Odense Univ Hosp, Dept Clin Biochem & Genet, DK-5000 Odense, Denmark
[5] Univ Copenhagen Hosp, DK-2100 Copenhagen, Denmark
关键词
manic depressive illness; genetic isolates; the Faroe Islands; bipolar affective disorder; chromosome; 18; psychiatry; genetics;
D O I
10.1097/00041444-199903000-00005
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The Faroe Islands are a small group of islands in the North Atlantic Ocean, situated between Norway, Iceland and Scotland. The origin of the population is thought to be a mixture of Norwegian, Danish and British. The islands were populated at the same time as Iceland, i.e. around 1100 years ago, and the size of the population was around, and occasionally below, 4000 inhabitants until 1800, after which it increased to its present-day level of around 45 000. The population is descended from Scandinavian and British ancestors. Because of the low number of founders and small size for many centuries, the Faroese population is perhaps the most valuable European population for genetic mapping of complex disease genes. The present study searched for haplotype sharing on chromosome 18 among eight lithium responding patients,vith bipolar affective disorder related, on average, 6.2 generations ago, using 30 DNA markers. In order to obtain as homogeneous a sample as possible, strict inclusion criteria based on severity of phenotype, geography and treatment response, were applied. Evidence suggestive of increased haplotype sharing on the distal part of chromosome 18q23 in the region implicated by Freimer and co-workers was found. However, methods of genetic analysis which might provide a conclusive result are not yet available. (C) 1999 Lippincott Williams & Wilkins.
引用
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页码:23 / 34
页数:12
相关论文
共 51 条
[1]   A susceptibility locus for bipolar affective disorder on chromosome 4q35 [J].
Adams, LJ ;
Mitchell, PB ;
Fielder, SL ;
Rosso, A ;
Donald, JA ;
Schofield, PR .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (05) :1084-1091
[2]   MODE OF INHERITANCE IN FAMILIES OF PATIENTS WITH LITHIUM-RESPONSIVE AFFECTIVE-DISORDERS [J].
ALDA, M ;
GROF, P ;
GROF, E ;
ZVOLSKY, P ;
WALSH, M .
ACTA PSYCHIATRICA SCANDINAVICA, 1994, 90 (04) :304-310
[3]   CHROMOSOME-18 DNA MARKERS AND MANIC-DEPRESSIVE ILLNESS - EVIDENCE FOR A SUSCEPTIBILITY GENE [J].
BERRETTINI, WH ;
FERRARO, TN ;
GOLDIN, LR ;
WEEKS, DE ;
DETERAWADLEIGH, S ;
NURNBERGER, JI ;
GERSHON, ES .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (13) :5918-5921
[4]   A locus for bipolar affective disorder on chromosome 4p [J].
Blackwood, DHR ;
He, L ;
Morris, SW ;
McLean, A ;
Whitton, C ;
Thomson, M ;
Walker, MT ;
Woodburn, K ;
Sharp, CM ;
Wright, AF ;
Shibasaki, Y ;
StClair, DM ;
Porteous, DJ ;
Muir, WJ .
NATURE GENETICS, 1996, 12 (04) :427-430
[5]   AMYLO-1,6-GLUCOSIDASE DEFICIENCY (GLYCOGENOSIS TYPE-III) IN FAROE-ISLANDS [J].
COHN, J ;
WANG, P ;
HAUGE, M ;
HENNINGSEN, K ;
JENSEN, B ;
SVEJGAARD, A .
HUMAN HEREDITY, 1975, 25 (02) :115-126
[6]   FAMILIAL COSEGREGATION OF MAJOR AFFECTIVE-DISORDER AND DARIERS-DISEASE (KERATOSIS-FOLLICULARIS) [J].
CRADDOCK, N ;
OWEN, M ;
BURGE, S ;
KURIAN, B ;
THOMAS, P ;
MCGUFFIN, P .
BRITISH JOURNAL OF PSYCHIATRY, 1994, 164 :355-358
[7]   Linkage analysis of families with bipolar illness and chromosome 18 markers [J].
Debruyn, A ;
Souery, D ;
Mendelbaum, K ;
Mendlewicz, J ;
Van Broeckhoven, C .
BIOLOGICAL PSYCHIATRY, 1996, 39 (08) :679-688
[8]   DISEASE GENE-MAPPING IN ISOLATED HUMAN-POPULATIONS - THE EXAMPLE OF FINLAND [J].
DELACHAPELLE, A .
JOURNAL OF MEDICAL GENETICS, 1993, 30 (10) :857-865
[9]   Haplotype identity between individuals who share a CFTR mutation allele ''identical by descent'': Demonstration of the usefulness of the haplotype-sharing concept for gene mapping in real populations [J].
deVries, HG ;
vanderMeulen, MA ;
Rozen, R ;
Halley, DJJ ;
Scheffer, H ;
tenKate, LP ;
Buys, CHCM ;
teMeerman, GJ .
HUMAN GENETICS, 1996, 98 (03) :304-309
[10]  
EISENSMITH RC, 1992, AM J HUM GENET, V51, P1355