Biomarkers intersect with the exposome

被引：82

作者：

Rappaport, Stephen M. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Sch Publ Hlth, Ctr Exposure Biol, Berkeley, CA 94720 USA

来源：

BIOMARKERS | 2012年 / 17卷 / 06期

关键词：

Biomarker; exposome; metabolomics; proteomics; EWAS; discovery; CHAIN FATTY-ACIDS; COLORECTAL-CANCER PATIENTS; MOLECULAR EPIDEMIOLOGY; CARDIOVASCULAR-DISEASE; MYOCARDIAL-ISCHEMIA; METABOLITE PROFILES; WIDE ASSOCIATION; GENE-EXPRESSION; RISK-FACTORS; HUMAN SERUM;

D O I：

10.3109/1354750X.2012.691553

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

The exposome concept promotes use of omic tools for discovering biomarkers of exposure and biomarkers of disease in studies of diseased and healthy populations. A two-stage scheme is presented for profiling omic features in serum to discover molecular biomarkers and then for applying these biomarkers in follow-up studies. The initial component, referred to as an exposome-wide-association study (EWAS), employs metabolomics and proteomics to interrogate the serum exposome and, ultimately, to identify, validate and differentiate biomarkers of exposure and biomarkers of disease. Follow-up studies employ knowledge-driven designs to explore disease causality, prevention, diagnosis, prognosis and treatment.

引用

页码：483 / 489

页数：7

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