Asymmetric division and polarity of neuroepithelial cells

被引：121

作者：

Huttner, WB

Brand, M

机构：

[1] Department of Neurobiology, Univ. Heidelberg, Im Neuenheimer F., Heidelberg

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0959-4388(97)80117-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuroepithelial cells, the progenitors to the CNS neurons and glia, undergo both symmetric and asymmetric divisions. Symmetric divisions underlie the proliferation of neuroepithelial cells that predominates early in CNS development. Asymmetric divisions are thought to generate the cell types derived from neuroepithelial cells, such as neurons. Insight into the mechanism of asymmetric division of neuroepithelial cells has come from two lines of research, the study of their epithelial polarity and the analysis of the expression of vertebrate homologues of proteins known to be involved in cell fate determination in Drosophila.

引用

页码：29 / 39

页数：11

共 71 条

[1] Loss of occludin and functional tight junctions, but not ZO-1, during neural tube closure - Remodeling of the neuroepithelium prior to neurogenesis [J].