Spectrally resolved bioluminescence optical tomography

被引：146

作者：

Dehghani, H

Davis, SC

Jiang, SD

Pogue, BW

Paulsen, KD

Patterson, MS

机构：

[1] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA

[2] Juravinski Canc Ctr, Hamilton, ON, Canada

[3] McMaster Univ, Hamilton, ON, Canada

来源：

OPTICS LETTERS | 2006年 / 31卷 / 03期

关键词：

D O I：

10.1364/OL.31.000365

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Spectrally resolved bioluminescence optical tomography is an approach to recover images of luciferase activity within a volume using multiwavelength emission data from internal bioluminescence sources. The underlying problem of uniqueness associated with nonspectrally resolved intensity-based bioluminescence tomography is highlighted. Reconstructed images of bioluminescence are presented by using as input both simulated and real multiwavelength data from a tissue-simulating phantom. The location of the internal bioluminescence is obtained with 1 mm accuracy. Further, the amplitude of the reconstructed source is proportional to the actual bioluminescence intensity. (c) 2006 Optical Society of America.

引用

页码：365 / 367

页数：3

共 9 条

[1] Tomographic bioluminescence imaging by use of a combined optical-PET (OPET) system: a computer simulation feasibility study [J].