Aspirin inhibits stress-induced increase in plasma glutamate, brain oxidative damage and ATP fall in rats

被引：32

作者：

De Cristóbal, J ^{[1
]}

Madrigal, JLM ^{[1
]}

Lizasoain, I ^{[1
]}

Lorenzo, P ^{[1
]}

Leza, JC ^{[1
]}

Moro, MA ^{[1
]}

机构：

[1] Univ Complutense, Fac Med, Dept Farmacol, E-28040 Madrid, Spain

来源：

NEUROREPORT | 2002年 / 13卷 / 02期

关键词：

ATP; glutathione; immobilisation; iNOS; lipid peroxidation; NF-kappa B; restraint; stress-induced neurodegeneration; TNF-alpha;

D O I：

10.1097/00001756-200202110-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The precise mechanisms by which stress induces brain damage are still being elucidated. The high-output, inducible isoform of nitric oxide (NO) synthase (NOS) is expressed in rat brain after immobilisation stress and its inhibition protects against cell damage in this condition. We have hereby explored some mechanisms involved in NOS expression and studied the effects of aspirin, a NSAID with neuroprotective actions, in this model. Acute (6 h) stress exposure in rats caused brain expression of NOS, an increase in plasma glutamate and brain TNF-alpha, induction of oxidative indicators in brain and a fall in brain ATP levels. Prior administration Of aspirin (10 mg/kg i.p.) inhibited all these effects caused by stress, suggesting possible therapeutic implications of this drug in this condition. NeuroReport 13:217-221 (C) 2002 Lippincott Williams Wilkins.

引用

页码：217 / 221

页数：5

共 27 条

[1] ANDERSON ME, 1985, METHOD ENZYMOL, V113, P548
[2] Implication of glutamate in the expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices
Cárdenas, A
Moro, MA
Hurtado, O
Leza, JC
Lorenzo, P
Castrillo, A
Bodelón, OG
Boscá, L
Lizasoain, I
[J]. JOURNAL OF NEUROCHEMISTRY, 2000, 74 (05) : 2041 - 2048
[3] DAS NP, 1987, BIOCHEM MED METAB B, V37, P256
[4] Inhibition of glutamate release via recovery of ATP levels accounts for a neuroprotective effect of aspirin in rat cortical neurons exposed to oxygen-glucose deprivation
De Cristóbal, J
Cárdenas, A
Lizasoain, I
Leza, JC
Fernández-Tomé, P
Lorenzo, P
Moro, MA
[J]. STROKE, 2002, 33 (01) : 261 - 267
[5] Neuroprotective effect of aspirin by inhibition of glutamate release after permanent focal cerebral ischaemia in rats
De Cristóbal, J
Moro, MA
Dávalos, A
Castillo, J
Leza, JC
Camarero, J
Colado, MI
Lorenzo, P
Lizasoain, I
[J]. JOURNAL OF NEUROCHEMISTRY, 2001, 79 (02) : 456 - 459
[6] Eltherington, 1992, DRUG DOSAGE LAB ANIM
[7] NITRIC-OXIDE - PATHOPHYSIOLOGICAL MECHANISMS
GROSS, SS
WOLIN, MS
[J]. ANNUAL REVIEW OF PHYSIOLOGY, 1995, 57 : 737 - 769
[8] PROTEIN DETERMINATION USING BICINCHONINIC ACID IN THE PRESENCE OF SULFHYDRYL-REAGENTS
HILL, HD
STRAKA, JG
[J]. ANALYTICAL BIOCHEMISTRY, 1988, 170 (01) : 203 - 208
[9] Acute decrease in net glutamate uptake during energy deprivation
Jabaudon, D
Scanziani, M
Gähwiler, BH
Gerber, U
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (10) : 5610 - 5615
[10] Stress: metaplastic effects in the hippocampus
Kim, JJ
Yoon, KS
[J]. TRENDS IN NEUROSCIENCES, 1998, 21 (12) : 505 - 509

← 1 2 3 →