The addition of rituximab to anthracycline-based chemotherapy significantly improves outcome in 'Western' patients with intravascular large B-cell lymphoma

被引：83

作者：

Ferreri, Andres J. M. ^{[1
,2
]}

Dognini, Giuseppina P. ^{[1
,2
]}

Bairey, Osnat ^{[3
]}

Szomor, Arpad ^{[4
]}

Montalban, Carlos ^{[5
]}

Horvath, Barbara ^{[6
]}

Demeter, Judit ^{[7
]}

Uziel, Lilj ^{[8
]}

Soffietti, Riccardo ^{[9
]}

Seymour, John F. ^{[10
]}

Ambrosetti, Achille ^{[11
]}

Willemze, Rein ^{[12
]}

Martelli, Maurizio ^{[13
]}

Rossi, Giuseppe ^{[14
]}

Candoni, Anna ^{[15
]}

De Renzo, Amalia ^{[16
]}

Doglioni, Claudio ^{[1
,2
,17
]}

Zucca, Emanuele ^{[18
]}

Cavalli, Franco ^{[18
]}

Ponzoni, Maurilio ^{[1
,2
,17
]}

机构：

[1] Ist Sci San Raffaele, Dept Oncol, Med Oncol Unit, I-20132 Milan, Italy

[2] Ist Sci San Raffaele, Dept Oncol, Unit Lymphoid Malignancies, I-20132 Milan, Italy

[3] Beilinson Med Ctr, Rabin Med Ctr, Div Haematol, Petah Tiqwa, Israel

[4] Univ Pecs, Dept Med 1, Pecs, Hungary

[5] Hosp Ramon & Cajal, Med Interna Serv, E-28034 Madrid, Spain

[6] Dept Dermatovenereol & Dermatooncol, Budapest, Hungary

[7] Semmelweis Univ, Dept Med 1, H-1085 Budapest, Hungary

[8] Osped San Paolo, Div Haematol, Milan, Italy

[9] Univ & San Giovanni Battista Hosp, Dept Neurosci, Div Neurooncol, Turin, Italy

[10] Univ Melbourne, Melbourne, Vic 3010, Australia

[11] Univ Verona, Sez Ematol, Dipartimento Med Interna & Sperimentale, I-37100 Verona, Italy

[12] Dutch Cutaneous Lymphoma Grp, Leiden, Netherlands

[13] Univ Roma La Sapienza, Div Haematol, Rome, Italy

[14] Spedali Civil Brescia, Div Hematol, I-25125 Brescia, Italy

[15] Policlin Univ, Udine, Italy

[16] Univ Naples Federico II, Div Hematol, Naples, Italy

[17] Ist Sci San Raffaele, Pathol Unit, Milan, Italy

[18] Ist Oncol Svizzera Italiana, Div Med Oncol, Bellinzona, Switzerland

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2008年 / 143卷 / 02期

关键词：

rituximab; intravascular large B-cell lymphoma; extranodal lymphoma; immunotherapy; anti-CD20; therapy;

D O I：

10.1111/j.1365-2141.2008.07338.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Some case reports and a Japanese series suggest benefit from the use of rituximab in patients with intravascular large B-cell lymphoma (IVL). Rituximab efficacy was evaluated in Western patients with IVL, comparing outcome of 10 patients treated with rituximab + chemotherapy (R-CT) and of 20 patients treated with chemotherapy alone (CT). There were no significant differences in patients' characteristics between the two subgroups. The addition of rituximab was associated with improved complete remission rate (90% vs. 50%; P = 0.04), event-free survival (3-year: 89% vs. 35%; P = 0.003) and overall survival (3-year: 89% vs. 38%; P = 0.01). In conclusion, rituximab may substantially change the dismal prognosis of IVL.

引用

页码：253 / 257

页数：5

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