Sex, AGility, and the regulation of alternative splicing

被引:27
作者
Graveley, BR [1 ]
机构
[1] Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT 06030 USA
关键词
D O I
10.1016/S0092-8674(02)00750-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Alternative splicing is an important means of regulating the expression of eukaryotic genes and enhancing protein diversity. A detailed examination of the Drosophila Sex-lethal gene has led to two significant discoveries-the role of the splicing factor SPF45 in defining the site of exon ligation, and that alternative splicing can be regulated at the second step.
引用
收藏
页码:409 / 412
页数:4
相关论文
共 20 条
[1]   Bimolecular exon ligation by the human spliceosome [J].
Anderson, K ;
Moore, MJ .
SCIENCE, 1997, 276 (5319) :1712-1716
[2]   PROTEIN-COMPONENTS SPECIFICALLY ASSOCIATED WITH PRESPLICEOSOME AND SPLICEOSOME COMPLEXES [J].
BENNETT, M ;
MICHAUD, S ;
KINGSTON, J ;
REED, R .
GENES & DEVELOPMENT, 1992, 6 (10) :1986-2000
[3]   Protein diversity from alternative splicing: A challenge for bioinformatics and post-genome biology [J].
Black, DL .
CELL, 2000, 103 (03) :367-370
[4]  
Burge CB, 1999, RNA WORLD, P525
[5]   The RNA splicing factor hSlu7 is required for correct 3′ splice-site choice [J].
Chua, K ;
Reed, R .
NATURE, 1999, 402 (6758) :207-210
[6]  
KRAINER AR, 1985, RA WELCH FDN C CHEM, P353
[7]   Splicing regulation at the second catalytic step by sex-lethal involves 3′ splice site recognition by SPF45 [J].
Lallena, MJ ;
Chalmers, KJ ;
Llamazares, S ;
Lamond, AI ;
Valcárcel, J .
CELL, 2002, 109 (03) :285-296
[8]   Alternative splicing of pre-mRNA: Developmental consequences and mechanisms of regulation [J].
Lopez, AJ .
ANNUAL REVIEW OF GENETICS, 1998, 32 :279-305
[9]   Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3′ splice site AG [J].
Merendino, L ;
Guth, S ;
Bilbao, D ;
Martinez, C ;
Valcárcel, J .
NATURE, 1999, 402 (6763) :838-841
[10]   Intron recognition comes of AGe [J].
Moore, MJ .
NATURE STRUCTURAL BIOLOGY, 2000, 7 (01) :14-16