H3K36me3 key to Polycomb-mediated gene silencing in lineage specification

被引：19

作者：

Abed, Jumana AlHaj ^{[1
]}

Jones, Richard S. ^{[1
]}

机构：

[1] So Methodist Univ, Dept Biol Sci, Dallas, TX 75275 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 12期

关键词：

GROUP PROTEIN; TUDOR DOMAIN; TRIMETHYLATION; METHYLATION; DEMETHYLASE; COMPLEX; PHF1; H3;

D O I：

10.1038/nsmb.2458

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A newly uncovered activity of a family of Polycomb-group proteins provides insight into the mechanisms by which active genes become repressed during the transition from pluripotency to restricted cell fates as stem cells undergo lineage specification.

引用

页码：1214 / 1215

页数：2

共 21 条

[1] Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity [J].

Ballare, Cecilia ;

Lange, Martin ;

Lapinaite, Audrone ;

Martin, Gloria Mas ;

Morey, Lluis ;

Pascual, Gloria ;

Liefke, Robert ;

Simon, Bernd ;

Shi, Yang ;

Gozani, Or ;

Carlomagno, Teresa ;

Aznar Benitah, Salvador ;

Di Croce, Luciano .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2012, 19 (12) :1257-+

[2] Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation [J].

Brien, Gerard L. ;

Gambero, Guillermo ;

O'Connell, David J. ;

Jerman, Emilia ;

Turner, Siobhan A. ;

Egan, Chris M. ;

Dunne, Eiseart J. ;

Jurgens, Maike C. ;

Wynne, Kieran ;

Piao, Lianhua ;

Lohan, Amanda J. ;

Ferguson, Neil ;

Shi, Xiaobing ;

Sinha, Krishna M. ;

Loftus, Brendan J. ;

Cagney, Gerard ;

Bracken, Adrian P. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2012, 19 (12) :1273-+

[3] Role of hPHF1 in H3K27 methylation and Hox gene silencing [J].

Cao, Ru ;

Wang, Hengbin ;

He, Jin ;

Erdjument-Bromage, Hediye ;

Tempst, Paul ;

Zhang, Yi .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (05) :1862-1872

[4] Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells [J].

Casanova, Miguel ;

Preissner, Tanja ;

Cerase, Andrea ;

Poot, Raymond ;

Yamada, Daisuke ;

Li, Xiangzhi ;

Appanah, Ruth ;

Bezstarosti, Karel ;

Demmers, Jeroen ;

Koseki, Haruhiko ;

Brockdorff, Neil .

DEVELOPMENT, 2011, 138 (08) :1471-1482

[5] Polycomb group protein complexes exchange rapidly in living Drosophila [J].

Ficz, G ;

Heintzmann, R ;

Arndt-Jovin, DJ .

DEVELOPMENT, 2005, 132 (17) :3963-3976

[6] Structure of an atypical Tudor domain in the Drosophila Polycomblike protein [J].

Friberg, Anders ;

Oddone, Anna ;

Klymenko, Tetyana ;

Mueller, Juerg ;

Sattler, Michael .

PROTEIN SCIENCE, 2010, 19 (10) :1906-1916

[7] A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell [J].

Hong, Zehui ;

Jiang, Jie ;

Lan, Li ;

Nakajima, Satoshi ;

Kanno, Shin-ichiro ;

Koseki, Haruhiko ;

Yasui, Akira .

NUCLEIC ACIDS RESEARCH, 2008, 36 (09) :2939-2947

[8] Inactive yet indispensable: the tale of Jarid2 [J].

Landeira, David ;

Fisher, Amanda G. .

TRENDS IN CELL BIOLOGY, 2011, 21 (02) :74-80

[9] Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1 [J].

Musselman, Catherine A. ;

Avvakumov, Nikita ;

Watanabe, Reiko ;

Abraham, Christopher G. ;

Lalonde, Marie-Eve ;

Hong, Zehui ;

Allen, Christopher ;

Roy, Siddhartha ;

Nunez, James K. ;

Nickoloff, Jac ;

Kulesza, Caroline A. ;

Yasui, Akira ;

Cote, Jacques ;

Kutateladze, Tatiana G. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2012, 19 (12) :1266-+

[10] Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes [J].

Nekrasov, Maxim ;

Klymenko, Tetyana ;

Fraterman, Sven ;

Papp, Bernadett ;

Oktaba, Katarzyna ;

Koecher, Thomas ;

Cohen, Adrian ;

Stunnenberg, Hendrik G. ;

Wilm, Matthias ;

Mueller, Juerg .

EMBO JOURNAL, 2007, 26 (18) :4078-4088

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