Myocardial revascularization in patients with severe ischemic left ventricular dysfunction. Long term follow-up in 141 patients

Objectives: The present study evaluates our experience with coronary bypass grafting in patients with EF less than or equal to 25%. Myocardial revascularization in this setting remains controversial because of concerns over operative mortality and morbidity and lack of functional and survival benefit. Materials and methods: One hundred and forty-one patients with coronary artery disease and left ventricular ejection fraction less than or equal to 25% underwent coronary artery bypass graft between January 1988 and December 1998. Mean age at operation was 63.3 years and 81.4% were male. The major indication for surgery was angina (114 patients, 80.8%). Ejection fraction (EF), left ventricular end diastolic pressure (LVEDP) and cardiac index (CI) were used to assess left ventricular function. The number of graft was 2.7 +/- 1.6/patient. Internal mammary artery was used in 119 patients (84.3%). Intra aortic balloon pump was placed preoperatively in 25 patients (17.7%). Five operative risk factors were associated with a higher mortality: emergency, female sex, LVEDP, Cl and NYHA class IV. Results: The operative mortality was 7% (10 patients). Left ventricular ejection fraction (assessed post operatively in 83 patients) improved from 22.2% preoperatively to 33.5% post operatively (P < 0.001), mean end diastolic volume index fell from 98 to 83 ml/m(2) following surgery. Survival at 2, 5 and 7 years was respectively 84 +/- 3%, 70 +/- 4% and 50 +/- 5%. Two variables were associated with increased long term survival: congestive heart failure (NYHA class lower than IV (P = 0.035) and cardiomegaly (P = 0.04) Conclusion: In patients with left ventricular dysfunction, myocardial revascularization can be performed relatively safely with good medium term survival and improvement in quality of life and in left ventricular function. Coronary artery bypass graft may be offered to patients with impaired ventricular function, but careful patient selection and management when considering these patients for operation should assess potentially reversible dysfunction. (C) 2001 Elsevier Science B.V. All rights reserved.