Tangled areas of Alzheimer brain have upregulated levels of exon 10 containing tau mRNA

被引：41

作者：

Yasojima, K ^{[1
]}

McGeer, EG ^{[1
]}

McGeer, PL ^{[1
]}

机构：

[1] Univ British Columbia, Dept Psychiat, Kinsmen Lab Neurol Res, Vancouver, BC V6T 1Z3, Canada

来源：

BRAIN RESEARCH | 1999年 / 831卷 / 1-2期

关键词：

hippocampus; entorhinal cortex; midtemporal gyrus; midfrontal gyrus; polymerase chain reaction; cerebellum;

D O I：

10.1016/S0006-8993(99)01486-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We measured the relative levels of exon 10 containing and exon 10 deleted tau mRNAs in multiple areas of Alzheimer disease (AD) and normal brain. Compared with normal brain, we found a 3.4-fold upregulation of exon 10 plus and a 1.9-fold downregulation of exon 10 minus mRNAs in areas of ED brain with a heavy burden of neurofibrillary tangles. These data suggest that tangle formation in AD is initially determined by transcriptional factors and is not exclusively caused by post-translational events. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：301 / 305

页数：5

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