Seasonal variation in bone density in postmenopausal women

We investigated seasonal variation in bone density by cross-sectional designs in two large cohorts of women (N = 2337) in Sweden. One cohort was strictly population-based (all 75 yr old, N = 1044), and one cohort was patient-based (age >= 55 yr, mean age 68, N = 1293). Each woman was assessed once and the inclusion was continuous throughout almost all days of the-year. Bone mineral density (BMD) of the total body, hip, and lumbar spine was determined by means of dual X-ray absorptiometry (DXA). For both cohorts, the BMD was similar in those assessed during the period April-September compared to those assessed during the period October-March. On the other hand, when women who had been assessed during July-December were compared with women assessed during January-June, we found the BMD to be LIP to 5% lower during July-December in all skeletal regions in the population-based sample, and 4% lower at the Ward's triangle and trochanter in the patient-based sample. After correction for small differences in age and weight, women of both cohorts who had been assessed during July-December still had lower BMD at the hip compared with women assessed during January-June. In conclusion, we found no variation in bone density during the period April-September compared to the period October-March in these two cohorts of postmenopausal women. In elderly women living at a northern latitude, BMD may be a few percent lower during the period July-December compared to the period January-June.