X-linked immunodeficiency affects the outcome of Schistosoma mansoni infection in the murine model

被引:33
作者
Gaubert, S
Da Costa, AV
Maurage, CA
Lima, ECS
Fontaine, J
Lafitte, S
Minoprio, P
Capron, A
Grzych, JM
机构
[1] Inst Pasteur, Ctr Immunol & Biol Parasitaire, INSERM, Unite U167, F-59019 Lille, France
[2] Inst Pasteur, Unite Parasitol Expt, F-75724 Paris, France
[3] CHRU Lille, Lab Anat Pathol C, F-59037 Lille, France
关键词
Schistosoma mansoni; BALB; Xid; CD5(+) B cells; interleukins; susceptibility;
D O I
10.1046/j.1365-3024.1999.00205.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The incidence of the X-linked immunodeficiency (Xid) on the outcome of Schistosoma mansoni infection has been evaluated through a comparative analysis of parasitological and immune parameters in two different mouse strains: control BALB/c and BALE. Xid mice which carry the Xid mutation and lack BI (CD5(+) B) cells. This study clearly demonstrates that infected BI cell-deficient animals display a higher susceptibility to S. mansoni infection as revealed by an increase in the tissue egg loads and a significantly elevated mortality, as well as an increase in the granuloma densities, The analysis of the humoral and the cellular responses, conducted in the same experimental conditions, indicates differences in terms of cytokine production after specific antigenic stimulation of splenocytes. Larger amounts of IFN-gamma and IL-4 are observed in BALE. Xid mice while IL-10 production is reduced In parallel, the study of the specific antibody isotype profiles shows higher amounts of specific IgE and IgG1 antibodies and lower amounts of IgM and IgA in BALE. Xid mice. Taken together, these observations support the idea that B cells are playing a role in the ability of mice to tolerate infection with Schistosoma mansoni.
引用
收藏
页码:89 / 101
页数:13
相关论文
共 61 条
[1]  
ALTBOUM I, 1992, ANN NY ACAD SCI, V651, P152
[2]  
ANDRADE ZILTON A., 1964, TRANS ROY SOC TROP MED HYG, V58, P53, DOI 10.1016/0035-9203(64)90068-9
[3]  
BOGEN SA, 1995, LAB INVEST, V73, P252
[4]   DELAYED HYPERSENSITIVITY-TYPE GRANULOMA FORMATION AND DERMAL REACTION INDUCED AND ELICITED BY A SOLUBLE FACTOR ISOLATED FROM SCHISTOSOMA MANSONI EGGS [J].
BOROS, DL ;
WARREN, KS .
JOURNAL OF EXPERIMENTAL MEDICINE, 1970, 132 (03) :488-+
[5]  
Brorson K, 1997, J IMMUNOL, V159, P135
[6]  
COFFMAN RL, 1986, J IMMUNOL, V136, P4538
[7]  
COLLEY DG, 1975, J IMMUNOL, V115, P150
[8]  
DOENHOFF M, 1978, IMMUNOLOGY, V35, P771
[9]   SUCCESSFUL T-CELL PRIMING IN B-CELL-DEFICIENT MICE [J].
EPSTEIN, MM ;
DIROSA, F ;
JANKOVIC, D ;
SHER, A ;
MATZINGER, P .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (04) :915-922
[10]  
FIDEL PL, 1990, J IMMUNOL, V145, P1257