Relationships of thigh muscle contractile and non-contractile tissue with function, strength, and age in boys with Duchenne muscular dystrophy

被引：78

作者：

Akima, Hiroshi ^{[1
,2
]}

Lott, Donovan ^{[2
]}

Senesac, Claudia ^{[2
]}

Deol, Jasjit ^{[2
]}

Germain, Sean ^{[2
]}

Arpan, Ishu ^{[2
]}

Bendixen, Roxanna ^{[3
]}

Sweeney, H. Lee ^{[5
]}

Walter, Glenn ^{[4
]}

Vandenborne, Krista ^{[2
]}

机构：

[1] Nagoya Univ, Res Ctr Hlth Phys Fitness & Sports, Chikusa Ku, Nagoya, Aichi 4648601, Japan

[2] Univ Florida, Dept Phys Therapy, Gainesville, FL 32610 USA

[3] Univ Florida, Dept Occupat Therapy, Gainesville, FL 32610 USA

[4] Univ Florida, Dept Physiol & Funct Genom, Gainesville, FL 32610 USA

[5] Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA

来源：

NEUROMUSCULAR DISORDERS | 2012年 / 22卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Duchenne muscular dystrophy; Muscle strength; Magnetic resonance imaging; CROSS-SECTIONAL AREA; INTRAMUSCULAR FAT; THERAPIES; TENSION; TORQUE; WOMEN; YOUNG; SIZE; MRI;

D O I：

10.1016/j.nmd.2011.06.750

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

The purpose of this study was to assess the contractile and non-contractile content in thigh muscles of patients with Duchenne muscular dystrophy (DMD) and determine the relationship with functional abilities. Magnetic resonance images of the thigh were acquired in 28 boys with DMD and 10 unaffected boys. Muscle strength, timed functional tests, and the Brookes Lower Extremity scale were also assessed. Non-contractile content in the DMD group was significantly greater than in the control group for six muscles, including rectus femoris, biceps femoris-long head and adductor magnus. Non-contractile content in the total thigh musculature assessed by MRI correlated with the Brookes scale (r(s) = 0.75) and supine-up test (r(s) = 0.68), as well as other functional measures. An age-related specific torque increase was observed in the control group (r(s) = 0.96), but not the DMD (r(s) = 0.06). These findings demonstrate that MRI measures of contractile and non-contractile content can provide important information about disease progression in DMD. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：16 / 25

页数：10

共 38 条

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