Human H5N1 influenza: Current insight into pathogenesis

被引：27

作者：

Tran Tan Thanh ^{[1
]}

van Doorn, H. Rogier ^{[1
,2
]}

de Jong, Menno D. ^{[1
,2
,3
]}

机构：

[1] Univ Oxford, Hosp Trop Dis, Clin Res Unit, Ho Chi Minh City, Vietnam

[2] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Ctr Clin Vaccinol & Trop Med, Oxford, England

[3] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2008年 / 40卷 / 12期

关键词：

H5N1; Influenza; Emerging infections; Zoonosis; Pathogenesis;

D O I：

10.1016/j.biocel.2008.05.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since their emergence as avian (1996) and zoonotic human pathogens (1997), H5N1 influenza viruses have become endemic among poultry in large parts of Asia, but outbreaks have also been seen in Africa and Europe. Transmission from animals to humans remains sporadic, but mortality of human infection is high (63%). To date, reported cases of human to human transmission have been rare. Patient and laboratory data suggest that highly efficient viral replication and the resulting intensified immune response of the human host are the determining factors in H5N1 pathogenesis and case fatality rate. Therefore, in the management of H5N1 disease (early) suppression of viral replication is key. The underlying biochemistry and cell biology of H5N1 pathogenesis and treatment are briefly discussed in this review. (c) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：2671 / 2674

页数：4

相关论文

共 35 条

[1]

Abdel-Ghafar AN, 2008, NEW ENGL J MED, V358, P261, DOI 10.1056/NEJMra0707279

[2] Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells [J].

Chan, MCW ;

Cheung, CY ;

Chui, WH ;

Tsao, SW ;

Nicholls, JM ;

Chan, YO ;

Chan, RWY ;

Long, HT ;

Poon, LLM ;

Guan, Y ;

Peiris, JSM .

RESPIRATORY RESEARCH, 2005, 6 (1)

[3] Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin [J].

Chandrasekaran, Aarthi ;

Srinivasan, Aravind ;

Raman, Rahul ;

Viswanathan, Karthik ;

Raguram, S. ;

Tumpey, Terrence M. ;

Sasisekharan, V. ;

Sasisekharan, Ram .

NATURE BIOTECHNOLOGY, 2008, 26 (01) :107-113

[4] Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? [J].

Cheung, CY ;

Poon, LLM ;

Lau, AS ;

Luk, W ;

Lau, YL ;

Shortridge, KF ;

Gordon, S ;

Guan, Y ;

Peiris, JSM .

LANCET, 2002, 360 (9348) :1831-1837

[5] The PB1-F2 protein of Influenza A virus: increasing pathogenicity by disrupting alveolar macrophages [J].

Coleman, J. Robert .

VIROLOGY JOURNAL, 2007, 4 (1)

[6] A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence [J].

Conenello, Gina M. ;

Zamarin, Dmitriy ;

Perrone, Lucy A. ;

Tumpey, Terrence ;

Palese, Peter .

PLOS PATHOGENS, 2007, 3 (10) :1414-1421

[7] Avian influenza A (H5N1) [J].

de Jong, MD ;

Hien, TT .

JOURNAL OF CLINICAL VIROLOGY, 2006, 35 (01) :2-13

[8] Brief report - Oseltamivir resistance during treatment of influenza A (H5N1) infection [J].

de Jong, MD ;

Thanh, TT ;

Khanh, TH ;

Hien, VM ;

Smith, GJD ;

Chau, NV ;

Cam, BV ;

Qui, PT ;

Ha, DQ ;

Guan, Y ;

Peiris, JSM ;

Hien, TT ;

Farrar, J .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (25) :2667-2672

[9] Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia [J].

de Jong, Menno D. ;

Simmons, Cameron P. ;

Thanh, Tran Tan ;

Hien, Vo Minh ;

Smith, Gavin J. D. ;

Chau, Tran Nguyen Bich ;

Hoang, Dang Minh ;

Chau, Nguyen Van Vinh ;

Khanh, Truong Huu ;

Dong, Vo Cong ;

Qui, Phan Tu ;

Van Cam, Bach ;

Ha, Do Quang ;

Guan, Yi ;

Peiris, J. S. Malik ;

Chinh, Nguyen Tran ;

Hien, Tran Tinh ;

Farrar, Jeremy .

NATURE MEDICINE, 2006, 12 (10) :1203-1207

[10] Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide [J].

Deyde, Varough M. ;

Xu, Xiyan ;

Bright, Rick A. ;

Shaw, Michael ;

Smith, Catherine B. ;

Zhang, Ye ;

Shu, Yuelong ;

Gubareva, Larisa V. ;

Cox, Nancy J. ;

Klimov, Alexander I. .

JOURNAL OF INFECTIOUS DISEASES, 2007, 196 (02) :249-257

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