Isochromosome 12p and maternal loss of 1p36 in a pediatric testicular germ cell tumor

被引：13

作者：

Stock, C

Strehl, S

Fink, FM

Bauer, S

Lion, T

Kreczy, A

Gadner, H

Ambros, PF

机构：

[1] PEDIAT UNIV HOSP INNSBRUCK, INNSBRUCK, AUSTRIA

[2] UNIV INNSBRUCK, INST PATHOL, A-6020 INNSBRUCK, AUSTRIA

来源：

CANCER GENETICS AND CYTOGENETICS | 1996年 / 91卷 / 02期

关键词：

D O I：

10.1016/0165-4608(95)00190-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Analysis of a pediatric germ cell tumor by conventional cytogenetic investigation and fluorescence in situ hybridization showed consistently the presence of two isochromosomes 12p, loss of the maternal band 1p36, and other numerical and structural chromosome changes. The rearrangements observed resulted mainly from breaks occurring at paracentromeric regions. This report represents the first description of i(12)(p10) in a pediatric testicular embryonal carcinoma. (C) Elsevier Science Inc., 1996

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页码：95 / 100

页数：6

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