Carotid plaque echomorphology and serum vascular endothelial growth factor levels

被引：8

作者：

Heliopoulos, I ^{[1
]}

Papazoglou, D

Piperidou, H

Vadikolias, K

Maltezos, E

Artemis, N

机构：

[1] Democritus Univ Thrace, Dept Neurol, Univ Hosp Alexandroupolis, GR-68100 Alexandroupolis, Greece

[2] Democritus Univ Thrace, Dept Internal Med 2, Univ Hosp Alexandroupolis, GR-68100 Alexandroupolis, Greece

[3] Aristotle Univ Thessaloniki, Dept Neurol, AHEPA Hosp, GR-54006 Thessaloniki, Greece

来源：

EUROPEAN NEUROLOGY | 2004年 / 51卷 / 02期

关键词：

angiogenesis; atherosclerosis; computer-assisted image processing; plaques; three-dimensional imaging; ultrasonography;

D O I：

10.1159/000076759

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neovascularization in atherosclerotic plaques plays an essential role in the progression and rupture of plaques. Vascular endothelial growth factor (VEGF) is an important angiogenic factor. Echomorphologic evaluation of carotid plaques using computer-assisted imaging was found to have a good correlation with the histology of the lesion. The aim of this study was to investigate whether the serum VEGF level could be a determinant of the echomorphology of the carotid plaque. In 28 carotid plaques causing 60-99% stenosis, serum VEGF levels and the mean gray value (MGV) of three-dimensional image of the carotid plaques were measured. A statistically significant inverse correlation was found between serum VEGF concentrations and MGVs (Spearman's correlation coefficient: -0.415, p = 0.028). Our finding indicates that in patients with greater than or equal to60% carotid stenosis the serum VEGF levels are associated with the echogenicity of the atherosclerotic plaque. Copyright (C) 2004 S. Karger AG, Basel.

引用

页码：104 / 108

页数：5

共 30 条

[1] Carotid plaque ultrasonic heterogeneity and severity of stenosis [J].