An Improved Bouveault-Blanc Ester Reduction with Stabilized Alkali Metals

被引：49

作者：

Bodnar, Brian S. ^{[1
]}

Vogt, Paul F. ^{[1
]}

机构：

[1] SiGNa Chem Inc, Proc Dev Serv, Monmouth Jct, NJ 08852 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 06期

关键词：

PRIMARY ALCOHOLS; SILICA-GEL; CORRESPONDING ACIDS;

D O I：

10.1021/jo802778z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Significantly improved Bouveault-Blanc conditions for ester reduction have been developed using sodium in silica gel (Na-SG), a free-flowing powder that can be easily handled in the open atmosphere. Primary alcohols were prepared in excellent yield from a variety of aliphatic esters under mild reaction conditions. The chemistry presented here is far safer than the classic Bouveault-Blanc reduction and is competitive with more modern hydride reduction methods.

引用

页码：2598 / 2600

页数：3

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