Mutations in ribosomal protein L16 and in 23S rRNA in enterococcus strains for which evernimicin MICs differ

被引：10

作者：

Zarazaga, M ^{[1
]}

Tenorio, C ^{[1
]}

Del Campo, R ^{[1
]}

Ruiz-Larrea, F ^{[1
]}

Torres, C ^{[1
]}

机构：

[1] Univ La Rioja, Area Bioquim & Biol Mol, Logrono 26006, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 11期

关键词：

D O I：

10.1128/AAC.46.11.3657-3659.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mutations in ribosomal protein L16 and in 23S rRNA were investigated in 22 Enterococcus strains of different species and for which the MICs of evernimicin differ (MICs, 0.023 to 16 mug/ml). Amino acid changes (Arg56His, Ile52Thr, or Arg51His) in protein L16 were found in seven strains, and a nucleotide G2535A mutation in 23S rRNA was found in 1 strain among 13 for which the MICs are greater than or equal to1 mug/ml.

引用

页码：3657 / 3659

页数：3

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