Construction of the simplest model to explain complex receptor activation kinetics

被引：9

作者：

Bywater, RP

Sorensen, A

Rogen, P

Hjorth, PG ^{[1
]}

机构：

[1] Tech Univ Denmark, Dept Math, DK-2800 Lyngby, Denmark

[2] Novo Nordisk AS, Biostruct Dept, DK-2760 Malov, Denmark

[3] Univ So Denmark, Maersk Inst Prod Technol, DK-5000 Odense, Denmark

来源：

JOURNAL OF THEORETICAL BIOLOGY | 2002年 / 218卷 / 02期

关键词：

D O I：

10.1006/jtbi.2002.3036

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We study the mathematical solutions to the kinetic equations arising from various simple ligand reactor models. Focusing on the prediction of the various models for the activity vs. concentration curve, we find that solutions to the kinetic equations arising from the so-called dimer model exibit features, observed in some experiments, most noticeably a distinct maximum in the activity curve. (C) 2002 Elsevier Science Lid. All rights reserved.

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页码：139 / 147

页数：9

相关论文

共 11 条

[1] TWO-DIMENSIONAL RHODOPSIN CRYSTALS FROM DISK MEMBRANES OF FROG RETINAL ROD OUTER SEGMENTS [J].

CORLESS, JM ;

MCCASLIN, DR ;

SCOTT, BL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (04) :1116-1120

[2]

DAM JE, 1981, BRIT J PHARMACOL, V74, P627

[3] Dimerization of G-protein-coupled receptors [J].

Dean, MK ;

Higgs, C ;

Smith, RE ;

Bywater, RP ;

Snell, CR ;

Scott, PD ;

Upton, GJG ;

Howe, TJ ;

Reynolds, CA .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (26) :4595-4614

[4] Mechanism of insulin and IGF-I receptor activation and signal transduction specificity - Receptor dimer cross-linking, bell-shaped curves, and sustained versus transient signaling [J].

DeMeyts, P ;

Urso, B ;

Christoffersen, CT ;

Shymko, RM .

RECEPTOR ACTIVATION BY ANTIGENS, CYTOKINES, HORMONES, AND GROWTH FACTORS, 1995, 766 :388-401

[5] A peptide derived from a beta(2)-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation [J].

Hebert, TE ;

Moffett, S ;

Morello, JP ;

Loisel, TP ;

Bichet, DG ;

Barret, C ;

Bouvier, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (27) :16384-16392

[6] A MODEL OF NONEXCLUSIVE BINDING OF AGONIST AND ANTAGONIST ON G-PROTEIN COUPLED RECEPTORS [J].

JARV, J .

JOURNAL OF THEORETICAL BIOLOGY, 1995, 175 (04) :577-582

[7] CONSTITUTIVE ACTIVITY OF RECEPTORS COUPLED TO GUANINE-NUCLEOTIDE REGULATORY PROTEINS [J].

LEFKOWITZ, RJ ;

COTECCHIA, S ;

SAMAMA, P ;

COSTA, T .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1993, 14 (08) :303-307

[8] BETA-ADRENERGIC RECEPTORS - EVIDENCE FOR NEGATIVE COOPERATIVITY [J].

LIMBIRD, LE ;

DEMEYTS, P ;

LEFKOWITZ, RJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1975, 64 (04) :1160-1168

[9]

RANG HP, 1987, PHARMACOLOGY, pCH1

[10]

Surya A, 1998, TRENDS PHARMACOL SCI, V19, P243