Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

被引：307

作者：

Hausenloy, Derek J. ^{[1
,2
,3
,4
,5
,6
]}

Garcia-Dorado, David ^{[7
,8
]}

Botker, Hans Erik ^{[9
]}

Davidson, Sean M. ^{[1
]}

Downey, James ^{[10
]}

Engel, Felix B. ^{[11
]}

Jennings, Robert ^{[12
]}

Lecour, Sandrine ^{[13
,14
]}

Leor, Jonathan ^{[15
,16
,17
]}

Madonna, Rosalinda ^{[18
,19
,20
,21
]}

Ovize, Michel ^{[22
,23
]}

Perrino, Cinzia ^{[24
]}

Prunier, Fabrice ^{[25
]}

Schulz, Rainer ^{[26
]}

Sluijter, Joost P. G. ^{[27
,28
]}

Van Laake, Linda W. ^{[29
]}

Vinten-Johansen, Jakob ^{[30
]}

Yellon, Derek M. ^{[1
,2
]}

Ytrehus, Kirsti ^{[31
]}

Heusch, Gerd ^{[32
]}

Ferdinandy, Peter ^{[33
,34
]}

机构：

[1] UCL, Hatter Cardiovasc Inst, 67 Chenies Mews, London WC1E 6HX, England

[2] Univ Coll London Hosp, Biomed Res Ctr, Natl Inst Hlth Res, 149 Tottenham Court Rd, London W1T 7DN, England

[3] Duke Natl Univ Singapore, Cardiovasc & Metab Disorders Program, 8 Coll Rd, Singapore 169857, Singapore

[4] Natl Heart Ctr Singapore, Natl Heart Res Inst Singapore, 5 Hosp Dr, Singapore 169609, Singapore

[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore

[6] St Bartholomews Hosp, Barts Heart Ctr, London, England

[7] Univ Autonoma Barcelona, Vall D Hebron Univ Hosp, Dept Cardiol, Passeig Vall dHebron 119-129, Barcelona 08035, Spain

[8] Univ Autonoma Barcelona, Res Inst, Passeig Vall dHebron 119-129, Barcelona 08035, Spain

[9] Aarhus Univ Hosp Skejby, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark

[10] Univ S Alabama, Dept Physiol & Cell Biol, Coll Med, 5851 USA Dr N,MSB 3074, Mobile, AL 36688 USA

[11] Friedrich Alexander Univ Erlangen Nurnberg, Inst Pathol, Dept Nephropathol, Expt Renal & Cardiovasc Res, Schlosspl 4, D-91054 Erlangen, Germany

[12] Duke Univ, Dept Cardiol, Durham, NC 27708 USA

[13] Univ Cape Town, Hatter Inst Cardiovasc Res Africa, Dept Med, Fac Hlth Sci, Chris Barnard Bldg,Anzio Rd, ZA-7925 Cape Town, Western Cape, South Africa

[14] Univ Cape Town, South African Med Res Council Interuniv Cape Hear, Fac Hlth Sci, Chris Barnard Bldg,Anzio Rd, ZA-7925 Cape Town, Western Cape, South Africa

[15] Sheba Med Ctr, Tamman Cardiovasc Res Inst, Tel Hashomer, Israel

[16] Tel Aviv Univ, Neufeld Cardiac Res Inst, Sheba Med Ctr, IL-5265601 Tel Hashomer, Israel

[17] Sheba Ctr Regenerat Med Stem Cell & Tissue Engn, IL-5265601 Tel Hashomer, Israel

[18] Univ G dAnnunzio, Ctr Aging Sci & Translat Med CESI MeT, Chieti, Italy

[19] Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Inst Cardiol, Chieti, Italy

[20] Texas Heart Inst, 6770 Bertner Ave, Houston, TX 77030 USA

[21] Univ Texas Med Sch Houston, Dept Internal Med, 6770 Bertner Ave, Houston, TX 77030 USA

[22] Hop Louis Pradel, Explorat Fonct Cardiovasc, 28 Ave Doyen Jean Lepine, F-69500 Bron, France

[23] Univ Claude Bernard Lyon, UMR CarMeN 1060, 43 Blvd 11 Novembre 1918, F-69100 Villeurbanne, France

[24] Univ Naples Federico II, Div Cardiol, Dept Adv Biomed Sci, Corso Umberto I 40, I-80138 Naples, Italy

[25] Univ Angers, Univ Hosp Angers, Dept Cardiol, 4 Rue Larrey, F-49100 Angers, France

[26] Justus Liebig Univ Giessen, Inst Physiol, Ludwigstr 23, D-35390 Giessen, Germany

[27] Univ Med Ctr Utrecht, Cardiol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[28] Univ Med Ctr Utrecht, UMC Utrecht Regenerat Med Ctr, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[29] Univ Med Ctr Utrecht, Div Heart & Lungs, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[30] Emory Univ, Dept Surg, Div Cardiothorac Surg, 201 Dowman Dr, Atlanta, GA 30322 USA

[31] UiT, Dept Med Biol, Cardiovasc Res Grp, Hansine Hansens Veg 18, N-9019 Tromso, Norway

[32] Univ Hosp Essen, West German Heart & Vasc Ctr, Inst Pathophysiol, Hufelandstr 55, D-45147 Essen, Germany

[33] Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, Nagyvarad Ter 4, H-1089 Budapest, Hungary

[34] Pharmahungary Grp, Graphisoft Pk,7 Zahony St, H-1031 Budapest, Hungary

来源：

CARDIOVASCULAR RESEARCH | 2017年 / 113卷 / 06期

关键词：

Cardioprotection; Ischaemia; Reperfusion; Myocardial Infarction; Ischaemic conditioning; ELEVATION MYOCARDIAL-INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; ISCHEMIA-REPERFUSION INJURY; INDUCED VENTRICULAR-FIBRILLATION; ATRIAL-NATRIURETIC-PEPTIDE; BYPASS GRAFT-SURGERY; LONG-TERM BENEFIT; MICROVASCULAR OBSTRUCTION; ARTERY-DISEASE; CYCLOSPORINE-A;

D O I：

10.1093/cvr/cvx049

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Ischaemic heart disease and the heart failure that often results, remain the leading causes of death and disability in Europe and worldwide. As such, in order to prevent heart failure and improve clinical outcomes in patients presenting with an acute ST-segment elevation myocardial infarction and patients undergoing coronary artery bypass graft surgery, novel therapies are required to protect the heart against the detrimental effects of acute ischaemia/reperfusion injury (IRI). During the last three decades, a wide variety of ischaemic conditioning strategies and pharmacological treatments have been tested in the clinic-however, their translation from experimental to clinical studies for improving patient outcomes has been both challenging and disappointing. Therefore, in this Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart, we critically analyse the current state of ischaemic conditioning in both the experimental and clinical settings, provide recommendations for improving its translation into the clinical setting, and highlight novel therapeutic targets and new treatment strategies for reducing acute myocardial IRI.

引用

页码：564 / 585

页数：22

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