The scarless heart

被引：20

作者：

Leferovich, JM ^{[1
]}

Heber-Katz, E ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2002年 / 13卷 / 05期

基金：

美国国家卫生研究院;

关键词：

cardiomyocytes; MRL mouse; scarring; stem cells;

D O I：

10.1016/S1084952102000885

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Over the past several years many mechanisms by which myocardial replacement could be achieved have been described. These include resident cardiac stem cells or circulating stem cells that can either differentiate into, or fuse to cardiomyocytes, or mature cells that can transdifferentiate into cardiomyocytes. However, the fact remains that after injury to the heart, the overriding response is scar formation with little myocardial replacement. One exception to this response is the MRL mouse, which heals with little scarring and shows nearly full myocardial replacement after injury. Results obtained with this model will be discussed.

引用

收藏

页码：327 / 333

页数：7

相关论文

共 84 条

[1]

Anversa P, 2000, Ital Heart J, V1, P91

[2] Myocyte renewal and ventricular remodelling [J].

Anversa, P ;

Nadal-Ginard, B .

NATURE, 2002, 415 (6868) :240-243

[3] Myocyte death in heart failure [J].

Anversa, P ;

Kajstura, J ;

Olivetti, G .

CURRENT OPINION IN CARDIOLOGY, 1996, 11 (03) :245-251

[4] Ventricular myocytes are not terminally differentiated in the adult mammalian heart [J].

Anversa, P ;

Kajstura, J .

CIRCULATION RESEARCH, 1998, 83 (01) :1-14

[5] MORPHOMETRIC STUDY OF EARLY POSTNATAL-DEVELOPMENT IN THE LEFT AND RIGHT VENTRICULAR MYOCARDIUM OF THE RAT .1. HYPERTROPHY, HYPERPLASIA, AND BINUCLEATION OF MYOCYTES [J].

ANVERSA, P ;

OLIVETTI, G ;

LOUD, AV .

CIRCULATION RESEARCH, 1980, 46 (04) :495-502

[6]

ARMAND O, 1983, ARCH ANAT MICROSC MO, V72, P163

[7] ONTOGENY OF THE SKIN AND THE TRANSITION FROM SCAR-FREE TO SCARRING PHENOTYPE DURING WOUND-HEALING IN THE POUCH YOUNG OF A MARSUPIAL, MONODELPHIS-DOMESTICA [J].

ARMSTRONG, JR ;

FERGUSON, MWJ .

DEVELOPMENTAL BIOLOGY, 1995, 169 (01) :242-260

[8] Evidence that human cardiac myocytes divide after myocardial infarction (Publication with Expression of Concern. See vol. 379, pg. 1870, 2018) [J].

Beltrami, AP ;

Urbanek, K ;

Kajstura, J ;

Yan, SM ;

Finato, N ;

Bussani, R ;

Nadal-Ginard, B ;

Silvestri, F ;

Leri, A ;

Beltrami, CA ;

Anversa, P .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (23) :1750-1757

[9]

BISCHOFF R, 1994, MYOGENESIS, V2, P97

[10] Regenerative healing of incisional wounds in midgestational murine hearts in organ culture [J].

Blewett, CJ ;

Cilley, RE ;

Ehrlich, HP ;

Blackburn, JH ;

Dillon, PW ;

Krummel, TM .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1997, 113 (05) :880-885

← 1 2 3 4 5 6 7 8 9 →