The scarless heart

被引：20

作者：

Leferovich, JM ^{[1
]}

Heber-Katz, E ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2002年 / 13卷 / 05期

基金：

美国国家卫生研究院;

关键词：

cardiomyocytes; MRL mouse; scarring; stem cells;

D O I：

10.1016/S1084952102000885

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Over the past several years many mechanisms by which myocardial replacement could be achieved have been described. These include resident cardiac stem cells or circulating stem cells that can either differentiate into, or fuse to cardiomyocytes, or mature cells that can transdifferentiate into cardiomyocytes. However, the fact remains that after injury to the heart, the overriding response is scar formation with little myocardial replacement. One exception to this response is the MRL mouse, which heals with little scarring and shows nearly full myocardial replacement after injury. Results obtained with this model will be discussed.

引用

收藏

页码：327 / 333

页数：7

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