Recent insights into atopic dermatitis and implications for management of infectious complications

被引：239

作者：

Boguniewicz, Mark ^{[1
]}

Leung, Donald Y. M.

机构：

[1] Natl Jewish Hlth, Dept Pediat, Div Pediat Allergy Immunol, Denver, CO 80206 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2010年 / 125卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Atopic dermatitis; filaggrin; epidermal barrier; Staphylococcus aureus; herpes simplex virus; superantigens; T regulatory cells; eczema herpeticum; antimicrobial peptides; probiotics; STAPHYLOCOCCUS-AUREUS COLONIZATION; SILVER-COATED TEXTILES; T-CELLS; METHICILLIN-RESISTANT; ECZEMA HERPETICUM; ENTEROTOXIN-B; DOUBLE-BLIND; VITAMIN-D; ANTIMICROBIAL PEPTIDES; MAINTENANCE TREATMENT;

D O I：

10.1016/j.jaci.2009.11.027

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Atopic dermatitis (AD) is a common complex disease that frequently follows a chronic relapsing course and affects the quality of life of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Patients with AD have a unique predisposition to colonization or infection by a number of microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. A multipronged approach directed at healing or protecting the skin barrier and addressing the immune dysregulation is necessary to improve the likelihood of successful outcomes. (J Allergy Clin Immunol 2010;125:4-13.)

引用

页码：4 / 13

页数：10

共 118 条

[1] Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report [J].

Akdis, Cezmi A. ;

Akdis, Mubeccel ;

Bieber, Thomas ;

Bindslev-Jensen, Carsten ;

Boguniewicz, Mark ;

Eigenmann, Philippe ;

Hamid, Qutayba ;

Kapp, Alexander ;

Leung, Donald Y. M. ;

Lipozencic, Jasna K. ;

Luger, Thomas A. ;

Muraro, Antonella ;

Novak, Natalija ;

Platts-Mills, Thomas A. E. ;

Rosenwasser, Lanny ;

Scheynius, Annika ;

Simons, F. Estelle R. ;

Spergel, Jonathan ;

Turjanmaa, Kristiina ;

Wahn, Ulrich ;

Weidinger, Stefan ;

Werfel, Thomas ;

Zuberbier, Torsten .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 118 (01) :152-169

[2] Serum IgE autoantibodies target keratinocytes in patients with atopic dermatitis [J].

Altrichter, Sabine ;

Kriehuber, Ernst ;

Moser, Julia ;

Valenta, Rudolf ;

Kopp, Tamara ;

Stingl, Georg .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2008, 128 (09) :2232-2239

[3] An update on the genetics of atopic dermatitis: Scratching the surface in 2009 [J].

Barnes, Kathleen C. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (01) :16-29

[4] A comparative study of impairment of quality of life in children with skin disease and children with other chronic childhood diseases [J].

Beattie, PE ;

Lewis-Jones, MS .

BRITISH JOURNAL OF DERMATOLOGY, 2006, 155 (01) :145-151

[5] Phenotype of atopic dermatitis subjects with a history of eczema herpeticum [J].

Beck, Lisa A. ;

Boguniewicz, Mark ;

Hata, Tissa ;

Schneider, Lynda C. ;

Hanifin, Jon ;

Gallo, Rich ;

Paller, Amy S. ;

Lieff, Susi ;

Reese, Jamie ;

Zaccaro, Daniel ;

Milgrom, Henry ;

Barnes, Kathleen C. ;

Leung, Donald Y. M. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 124 (02) :260-269

[6] Twice weekly fluticasone propionate added to emollient maintenance treatment to reduce risk of relapse in atopic dermatitis: randomised, double blind, parallel group study [J].

Berth-Jones, J ;

Damstra, RJ ;

Golsch, S ;

Livden, JK ;

Van Hooteghem, O ;

Allegra, F ;

Parker, CA .

BRITISH MEDICAL JOURNAL, 2003, 326 (7403) :1367-1370

[7] Mechanisms of disease: Atopic dermatitis [J].

Bieber, Thomas .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (14) :1483-1494

[8] IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis [J].

Bilsborough, J ;

Leung, DYM ;

Maurer, M ;

Howell, M ;

Boguniewcz, M ;

Yao, L ;

Storey, H ;

LeCiel, C ;

Harder, B ;

Gross, JA .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (02) :418-425

[9] Interventions to reduce Staphylococcus aureus in the management of atopic eczema [J].

Birnie, Andrew J. ;

Bath-Hextall, Fiona J. ;

Ravenscroft, Jane Catherine ;

Williams, Hywel C. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2008, (03)

[10] Atopic dermatitis [J].

Boguniewicz, M ;

Leung, DYM .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (02) :S475-S480

← 1 2 3 4 5 6 7 8 9 10 →