Lysophosphatidic acid and sphingosine 1-phosphate: Two lipid villains provoking cardiovascular diseases?

被引：13

作者：

Siess, W

Essler, M

Brandl, R

机构：

[1] Univ Munich, Klinikum Innenstadt, Inst Prophylaxe & Epidemiol Kreislaufkrankheiten, D-80336 Munich, Germany

[2] Tech Univ Munich, Klinikum Rechts Isar, Dept Vasc Surg, D-81675 Munich, Germany

来源：

IUBMB LIFE | 2000年 / 49卷 / 03期

关键词：

atherosclerosis; Edg receptors; endothelial cell; LDL; lysophosphatidic acid; macrophage; platelet; smooth muscle cell; sphingosine-1; phosphate; thrombosis;

D O I：

10.1080/713803618

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lysophosphatidic acid (LPA) and sphingosine I-phosphate (S1P) are potent bioactive lipids with specific and multiple effects on cells of the vessel wall and blood platelets, In this paper we suggest that these lipid molecules are involved in atherogenesis, pathological vasoconstriction, plaque rupture, and intravascular thrombus formation, which leads us to propose new strategies for the prevention and therapy of cardiovascular diseases. The conclusions are hypothetical, in that the studies were so far mainly carried out on isolated cells or cultured cells in vitro and the results were extrapolated to the situation in vivo.

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页码：167 / 171

页数：5

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