Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke

被引：55

作者：

McColl, Barry W. ^{[1
]}

Rose, Nicola ^{[1
]}

Robson, Fiona H. ^{[1
]}

Rothwell, Nancy J. ^{[1
]}

Lawrence, Catherine B. ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2010年 / 30卷 / 02期

基金：

英国医学研究理事会;

关键词：

blood-brain barrier; haemorrhagic transformation; leptin; MMP-9; obesity; stroke; TRANSIENT CEREBRAL-ISCHEMIA; INSULIN-RESISTANCE; INFLAMMATION; INJURY; DYSFUNCTION; RESPONSES; MASS;

D O I：

10.1038/jcbfm.2009.217

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is an independent risk factor for stroke and is associated with poorer outcome after stroke. We investigated whether this poorer outcome is related to brain microvascular disruption. Focal cerebral ischaemia was induced in lean or obese (ob/ob) mice by transient middle cerebral artery occlusion. The incidence of haemorrhagic transformation and the volume of ischaemic brain damage were significantly greater in obese mice. Blood-brain barrier permeability and brain microvascular MMP-9 expression were also markedly increased in obese mice. These effects were independent of leptin or glycaemic status, suggesting that obesity potentiates brain microvascular disruption after experimental stroke. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 267-272; doi: 10.1038/jcbfm.2009.217; published online 14 October 2009

引用

页码：267 / 272

页数：6

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