Borrelia burgdorferi genes selectively expressed in ticks and mammals

被引:39
作者
deSilva, AM
Fikrig, E
机构
[1] Section of Rheumatology, Department of Internal Medicine, New Haven, CT 06520-8031
[2] Yale University School of Medicine, New Haven, CT 06520-8031
来源
PARASITOLOGY TODAY | 1997年 / 13卷 / 07期
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0169-4758(97)01074-0
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Lyme disease is a tick-borne infection caused by the spirochete Borrelia burgdorferi. Recent studies have focused on how the Lyme disease bacterium overcomes the challenges faced by an organism that depends on a vector-borne life style. These studies indicate that the spirochete expresses different surface proteins at different stages of its life. Here, Aravinda de Silva and Erol Fikrig review the evidence for differential gene expression and discuss the implications of these findings for the Lyme disease vaccine that is currently being tested in human trials.
引用
收藏
页码:267 / 270
页数:4
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