Angiotensin II and the heart - On the intracrine renin-angiotensin system

被引：230

作者：

De Mello, WC

Danser, AHJ

机构：

[1] Univ Puerto Rico, Dept Pharmacol, San Juan, PR 00936 USA

[2] Erasmus Univ, Dept Pharmacol, NL-3000 DR Rotterdam, Netherlands

来源：

HYPERTENSION | 2000年 / 35卷 / 06期

关键词：

angiotensin; heart; hypertrophy; receptors; renin; signal transduction;

D O I：

10.1161/01.HYP.35.6.1183

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The active end product of the renin-angiotensin system, angiotensin II (Ang II), through the activation of specific Ang II receptors, regulates cardiac contractility, cell coupling, and impulse propagation and is involved in cardiac remodeling, growth, and apoptosis. We review these subjects, as well as the second messengers that are involved, and the synthesis of Ang II in the heart under normal and pathological conditions. Finally, we discuss the possibility that there is an intracrine renin-angiotensin system in the heart that plays a role in the control of cell communication and inward Ca2+ current.

引用

收藏

页码：1183 / 1188

页数：6

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