Selective suppression of hippocampal ripples impairs spatial memory

被引：973

作者：

Girardeau, Gabrielle ^{[1
]}

Benchenane, Karim ^{[1
]}

Wiener, Sidney I. ^{[1
]}

Buzsaki, Gyoergy ^{[2
]}

Zugaro, Michael B. ^{[1
]}

机构：

[1] CNRS, Coll France, Lab Physiol Percept & Act, Paris, France

[2] Rutgers State Univ, Ctr Mol & Behav Neurosci, Newark, NJ 07102 USA

来源：

NATURE NEUROSCIENCE | 2009年 / 12卷 / 10期

基金：

美国国家卫生研究院;

关键词：

SLOW-WAVE SLEEP; REACTIVATION; OSCILLATIONS; STATE;

D O I：

10.1038/nn.2384

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.

引用

页码：1222 / 1223

页数：2

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