Synthesis of 3-(beta-D-ribofuranosyl)-2-fluoropyridine and 3-(beta-D-ribofuranosyl)-pyridin-2-one

被引：27

作者：

MatulicAdamic, J

Beigelman, L

机构：

[1] Department of Organic Chemistry, Ribozyme Pharmaceuticals Inc., Boulder, CO 80301

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 02期

关键词：

D O I：

10.1016/S0040-4039(96)02289-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyridin-2-one C-nucleoside 13 was prepared in 7 steps from 2-fluoropyridine 1 and D-ribono-1,4-lactone 2. The successful approach to beta-ribofuranosides 12 and 13 consisted of the reductive opening of the furanose ring of hemiacetal 3 followed by intramolecular Mitsunobu cyclization. Copyright (C) 1996 Elsevier Science Ltd

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页码：203 / 206

页数：4

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