The bactericidal action of penicillin: new clues to an unsolved mystery

被引：93

作者：

Bayles, KW ^{[1
]}

机构：

[1] Univ Idaho, Dept Microbiol Mol Biol & Biochem, Moscow, ID 83844 USA

来源：

TRENDS IN MICROBIOLOGY | 2000年 / 8卷 / 06期

关键词：

D O I：

10.1016/S0966-842X(00)01762-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The Staphylococcus aureus lrgAB operon was recently shown to inhibit extracellular murein hydrolase activity and increase tolerance to penicillin. Further characterization of this operon could provide novel insight into the dynamics of S. aureus cell wall metabolism and the mechanism of penicillin-induced lethality.

引用

页码：274 / 278

页数：7

共 19 条

[1]

Identification of LytSR-regulated genes from Staphylococcus aureus [J].

Brunskill, EW ;

Bayles, KW .

JOURNAL OF BACTERIOLOGY, 1996, 178 (19) :5810-5812

[2]

Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus [J].

Brunskill, EW ;

Bayles, KW .

JOURNAL OF BACTERIOLOGY, 1996, 178 (03) :611-618

[3]

Opposing roles of the Staphylococcus aureus virulence regulators, Agr and Sar, in Triton X-100- and penicillin-induced autolysis [J].

Fujimoto, DF ;

Bayles, KW .

JOURNAL OF BACTERIOLOGY, 1998, 180 (14) :3724-3726

[4]

LETHAL ACTION OF BACTERIOPHAGE-GAMMA S-GENE [J].

GARRETT, JM ;

YOUNG, R .

JOURNAL OF VIROLOGY, 1982, 44 (03) :886-892

[5]

The Staphylococcus aureus lrgAB operon modulates murein hydrolase activity and penicillin tolerance [J].

Groicher, KH ;

Firek, BA ;

Fujimoto, DF ;

Bayles, KW .

JOURNAL OF BACTERIOLOGY, 2000, 182 (07) :1794-1801

[6]

ACTIVITY OF MUREIN HYDROLASES IN SYNCHRONIZED CULTURES OF ESCHERICHIA-COLI [J].

HAKENBECK, R ;

MESSER, W .

JOURNAL OF BACTERIOLOGY, 1977, 129 (03) :1239-1244

[7]

2 BACTERICIDAL TARGETS FOR PENICILLIN IN PNEUMOCOCCI - AUTOLYSIS-DEPENDENT AND AUTOLYSIS-INDEPENDENT KILLING MECHANISMS [J].

MOREILLON, P ;

MARKIEWICZ, Z ;

NACHMAN, S ;

TOMASZ, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (01) :33-39

[8]

Signal transduction by a death signal peptide: Uncovering the mechanism of bacterial killing by penicillin [J].

Novak, P ;

Charpentier, E ;

Braun, JS ;

Tuomanen, E .

MOLECULAR CELL, 2000, 5 (01) :49-57

[9]

Identification of a Streptococcus pneumoniae gene locus encoding proteins of an ABC phosphate transporter and a two-component regulatory system [J].

Novak, R ;

Cauwels, A ;

Charpentier, E ;

Tuomanen, E .

JOURNAL OF BACTERIOLOGY, 1999, 181 (04) :1126-1133

[10]

Penicillin tolerance genes of Streptococcus pneumoniae:: the ABC-type manganese permease complex Psa [J].

Novak, R ;

Braun, JS ;

Charpentier, E ;

Tuomanen, E .

MOLECULAR MICROBIOLOGY, 1998, 29 (05) :1285-1296

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