The immune responses to bacterial antigens encountered in vivo at mucosal surfaces

被引：6

作者：

Dougan, G ^{[1
]}

Ghaem-Maghami, M ^{[1
]}

Pickard, D ^{[1
]}

Frankel, G ^{[1
]}

Douce, G ^{[1
]}

Clare, S ^{[1
]}

Dunstan, S ^{[1
]}

Simmons, C ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Biochem, London SW7 2AZ, England

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES | 2000年 / 355卷 / 1397期

关键词：

mucosal vaccines; IgA; Citrobacter; enterotoxins;

D O I：

10.1098/rstb.2000.0610

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mammals have evolved a sophisticated immune system For handling antigens encountered at their mucosal surfaces. The way in which mucosally delivered antigens are handled influences our ability to design effective mucosal vaccines. Live attenuated derivatives of pathogens are one route towards the development of mucosal vaccines. However, some molecules, described as mucosal immunogens, are inherently immunogenic at mucosal surfaces. Studies on mucosal immunogens may facilitate the identification of common characteristics that contribute to mucosal immunogenicity and aid the development of novel, non-living mucosal vaccines and immunostimulators.

引用

页码：705 / 712

页数：8

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